Evidence map›Paper›PMID 40546631›Full record

ArticleCureus2025

Evaluation of the Relationship Between Nitrate Use and the Prevalence of Colorectal Cancers in the United States.

Alex N Egbuchiem, Okelue E Okobi, Oluwadamilola D Odutola, Christiana A Igbenabor, Uzoma N Okey-Ndeche, Oluwatobiloba Omotunde, Tosin Ayantoyinbo, Obinna C Abonyi, Oghenemaro O Oghotuoma, Ogechukwu H Nnabude and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alex N EgbuchiemPublic Health Research, College of Public Health, University of Nebraska Medical Center (UNMC), Omaha, USA.
Okelue E OkobiFamily Medicine, IMG Research Academy and Consulting LLC, Homestead, USA.
Oluwadamilola D OdutolaInternal Medicine, Medical University of South Carolina, Florence, USA.
Christiana A IgbenaborInternal Medicine, St. John's Episcopal Hospital, New York, USA.
Uzoma N Okey-NdecheInternal Medicine, Kingston Public Hospital, Kingston, JAM.
Oluwatobiloba OmotundeInternal Medicine, American International School of Medicine, Atlanta, USA.
Tosin AyantoyinboInternal Medicine, BronxCare Health System, New York, USA.
Obinna C AbonyiInternal Medicine, Spartan Health Sciences University, St. Lucia, UMI.
Oghenemaro O OghotuomaGeneral Internal Medicine, Walsall Healthcare NHS Trust, Walsall, GBR.
Ogechukwu H NnabudeDermatology, Psychiatry, Cardiology, Internal Medicine, Family Medicine, Windsor University School of Medicine, Houston, USA.
Chuka G NwumeInternal Medicine, St. John Episcopal Hospital, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Exposure to nitrate through contaminated drinking water has been suggested as a potential risk factor for colorectal cancer (CRC). However, ecological evidence across the U.S. states remains limited. This study aims to examine the association between average nitrate concentrations and CRC incidence across 31 U.S. states. Methods An ecological analysis was conducted using data from the Centers for Disease Control and Prevention's (CDC's) Environmental Public Health Tracking Network and United States Cancer Statistics (2017-2021). Simple linear regression and Pearson correlation analyses were performed, stratified by gender. Results No significant associations were observed between nitrate concentrations and CRC incidence in both strata. Correlations were weak and non-significant.  Conclusions In our study, state-level nitrate exposure was not significantly linked to CRC incidence. Further individual-level studies are recommended.

Indexed as

alkyl nitritescolorectal cancercolorectal cancer (crc)correlationecological studynitrate exposurenitratespublic health and safetyunited states

Identifiers

PMID40546631
PMCPMC12179813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.