ArticleCureus2025
Imaging Features of Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Intraosseous adenoid cystic carcinoma (ACC) of the mandible is an exceedingly rare malignancy. Its subtle onset and aggressive biological behavior, characterized by perineural invasion, present significant diagnostic and therapeutic challenges. We present a case involving a 68-year-old male who experienced persistent pain and swelling in the right hemimandible. Imaging studies using computed tomography (CT) revealed an ill-defined, osteolytic lesion affecting the right hemimandible, leading to cortical destruction. Magnetic resonance imaging (MRI) exhibited an enhancing mass in the right hemimandible, along with evidence of perineural spread along the inferior alveolar nerve. Histopathological analysis confirmed the diagnosis of adenoid cystic carcinoma, displaying a predominant cribriform pattern. The patient subsequently underwent segmental mandibulectomy, followed by adjuvant radiotherapy. This case highlights the essential roles of CT and MRI in the early detection, characterization, and surgical planning for intraosseous ACC. It is crucial for radiologists and clinicians to maintain a high index of suspicion when assessing destructive mandibular lesions, especially those that exhibit perineural spread. Timely diagnosis and a multidisciplinary management approach are vital for optimizing outcomes in this aggressive tumor.
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