ArticleCureus2025
Heterotopic Ossification After COVID-19: A Case Report and Review of Literature.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a 31-year-old woman hospitalized for approximately two months for coronavirus disease 2019 (COVID-19) pneumonia. Under sedation, she received physiotherapy to prevent joint contractures. When weaning from the mechanical ventilator began, she complained of pain and limited range of motion in her bilateral hip and knee joints. Radiography and computed tomography revealed non-traumatic heterotopic ossification (HO) in the bilateral vastus medialis and hips. Range-of-motion exercises were discontinued, and treatment with indomethacin and etidronate disodium was started. Alkaline phosphatase, an index of disease activity, peaked 15-fold higher than the normal range but decreased to near-normal levels four months after treatment. She could walk with a T-cane after rehabilitation, although her range of motion remained limited. If a COVID-19 patient has joint pain and is immobilized for a long time, HO should be considered accordingly.
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