ArticleCureus2025
Epidemiological Trends and Treatment Outcomes: Findings of a TB Survey From Selected Districts of Madhya Pradesh, India.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectiveTuberculosis (TB) remains a significant public health challenge in India, particularly in Madhya Pradesh. In this study, we aimed to examine epidemiological trends and treatment outcomes in TB patients in the Datia and Tikamgarh districts of Madhya Pradesh, from 2018 to 2022, to inform targeted TB control strategies.
methodsWe conducted a retrospective observational study using data from the National TB Elimination Program (NTEP), accessed through the Nikshay portal (a Government of India initiative). We analyzed trends in TB notifications, rates of microbiological confirmation, treatment outcomes, and co-infections. Statistical tests, including the Mann-Whitney U test, Kruskal-Wallis test, and chi-square test, were employed, with a p-value of less than 0.05 indicating statistical significance.
resultsIn Datia, the proportion of pediatric TB cases decreased from 6% to 3% (p = 0.04), while extrapulmonary TB (EPTB) cases rose from 11.3% to 13.8% (p = 0.02). Notifications from the private sector significantly increased from 4% to 28% (p = 0.03), whereas drug-resistant TB (DR-TB) cases fell from 2% to 1% (p = 0.02). TB-related mortality rose from 3.28% to 3.93% (p = 0.008), with the proportion of patients lost to follow-up remaining stable at 9%-10% (p = 0.02). In Tikamgarh, pediatric TB rates declined from 7.7% to 6.3% (p = 0.04), and EPTB cases increased from 4.77% to 9.37% (p = 0.02). Notifications from the private sector surged from 1.13% to 20.75% (p = 0.03). DR-TB rates decreased from 4.33% to 1% (p = 0.02), but TB-related mortality increased from 1.87% to 5.46% (p = 0.008). The rate of patients lost to follow-up improved slightly, decreasing from 12.71% to 10.09% (p = 0.02).
conclusionThe reduction in pediatric TB and DR-TB indicates progress in diagnosis and treatment adherence. However, the rising incidence of EPTB and increasing mortality rates highlight ongoing challenges. Enhancing private sector involvement, improving patient adherence, and integrating HIV-TB care are crucial for achieving India's TB elimination objectives.
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