ArticleCureus2025
Comparative X-ray Diffraction Analysis of the Hydroxyapatite Crystal Structure in Developing and Mature Lumbar Vertebrae.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ultrastructural characteristics of bone mineral composition during vertebral development remain incompletely understood. This study investigated the crystallographic parameters of hydroxyapatite in L3 vertebrae, comparing samples from newborn (n = 12) and adult (n = 12) specimens. X-ray diffraction analysis was performed using a DRON-3 diffractometer with copper Kα radiation (λ = 0.15433 nm) operating at 30 kV and 20 mA. Diffraction patterns were recorded from 2° to 37° at 1°/min, focusing on the characteristic hydroxyapatite peaks in the 30-34° range. Unit cell parameters were calculated using the (211), (112), and (300) reflections, while crystallite sizes were determined using the Scherrer method. Results revealed significant differences in crystallographic parameters between age groups, with adult samples showing larger crystallite sizes (18.12 ± 0.87 nm vs. 8.92 ± 0.25 nm, p < 0.001) and more defined diffraction peaks. The hexagonal unit cell parameters also differed significantly, with mature bone exhibiting increased lattice parameters in both the a-axis (9.451 ± 0.014 Å vs. 9.391 ± 0.014 Å, p < 0.001) and c-axis length (6.891 ± 0.010 Å vs. 6.860 ± 0.017 Å, p < 0.001) compared to developing bone. While adult specimens showed trends toward greater crystallinity with lower amorphous calcium (-10.76 wt%) and higher crystalline calcium (+2.60 wt%), these differences did not reach statistical significance. These findings provide new insights into the maturation process of bone mineral structure and may contribute to understanding age-related changes in bone mechanical properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.