ArticleCureus2025
Calciphylaxis: A Rare Manifestation of a Common Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calciphylaxis is a rare complication, typically observed in patients with end-stage chronic kidney disease (CKD), in the presence of risk factors such as secondary hyperparathyroidism, female sex, and diabetes mellitus, among others. It is characterized by painful cutaneous lesions resulting from calcification of arterioles, leading to vascular occlusion, tissue ischemia, and necrosis. We report the case of a 71-year-old woman with a history of CKD, Kidney Disease: Improving Global Outcomes G5 (KDIGO G5), secondary to diabetic nephropathy. As a relevant risk factor, she presented with secondary hyperparathyroidism associated with renal disease. She was admitted to the Emergency Department with erythematous and edematous plaques on both lower limbs, accompanied by severe pain. Laboratory evaluation revealed normocytic normochromic anemia, hyperphosphatemia, normal serum calcium levels, and elevated parathyroid hormone (PTH). The patient was hospitalized for etiological investigation. A skin biopsy obtained during hospitalization confirmed the diagnosis of calciphylaxis, revealing vascular calcifications and panniculitis. Treatment was initiated with opioids for pain control and topical heparinoid for the management of skin lesions. Following discharge, the patient remains under follow-up at the Nephrology clinic, with no recurrence of cutaneous lesions. This case underscores the importance of early diagnosis and a multidisciplinary approach in the management of calciphylaxis, a rare but potentially life-threatening condition associated with high mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.