ArticleCureus2025
Drug-Induced Acute Liver Injury Due to Tamoxifen Prophylaxis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 41-year-old female was diagnosed with stage II ductal breast cancer in November 2023. The patient subsequently underwent a bilateral mastectomy and was started on tamoxifen 20 mg as post-operative adjuvant therapy in December 2023. Surveillance positron emission tomography (six months post-mastectomy) confirmed no cancer recurrence prior to symptom onset. Following abdominal pain, nausea and vomiting, pruritus, and jaundice, in the context of an elevated bilirubin level and a 1.5 mm gallstone, tamoxifen treatment was discontinued in July 2024. In August 2024, the patient presented with recurrent nausea and vomiting, increased abdominal pain, worsening pruritus and jaundice, debilitating back pain, and a weight loss of 20.87 kg. The patient was admitted to the hospital for further workup. Her bilirubin levels were found to be 17.9 mg/dl (normal range: 0.1-1.2 mg/dL). Following subsequent labs and scans such as a hepatobiliary iminodiacetic acid scan, liver biopsy, computerized tomography of the lumbar spine, magnetic resonance imaging of the lumbar spine and bilateral hips, anti-smooth muscle antibody test, and more diagnostic testing, it was determined that the patient was suffering from drug-induced liver injury. After the initiation of steroids and ursodiol, her bilirubin measurements decreased. The patient reported resolution of symptoms a month later, as her bilirubin levels had declined from 17.9 to 2.3 mg/dL over four weeks. This unique presentation of tamoxifen-induced acute liver injury is reversible, and patients on tamoxifen need a frequent comprehensive metabolic panel to detect possible liver injury preemptively.
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