ArticleRisk management and healthcare policy2025
The Impact of Triglyceride-Glucose Index on Carotid Atherosclerosis: A Prospective Cohort Study in Middle Aged and Elderly Low-Income in Rural Chinese.
Article in Risk management and healthcare policy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Triglyceride-glucose index as a cardiovascular risk marker: updated evidence, limitations, and future perspectives.Lipids in health and disease · 2026Review
- Association of triglyceride-glucose index with carotid atherosclerosis in the general population: a case-control study of 14,535 participants.BMC cardiovascular disorders · 2026Article
- Association of Composite Metabolic Indices and Oxidative Stress Biomarkers with Coronary Atherosclerosis Detected by CT Angiography in Premenopausal Women with Metabolic Syndrome.Vascular health and risk management · 2026Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
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Authors and funding
8 authors.
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Abstract
Background: Atherosclerotic cardiovascular disease (ASCVD) is a major global health burden. The triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, is associated with atherosclerosis, but its role in predicting carotid plaque and intima-media thickness (IMT) changes remains unclear. This study aimed to assess the relationship between the TyG index and carotid plaque incidence and IMT changes over a six-year period in a cohort of middle-aged and elderly individuals with low income and low education in rural China. Methods: The study was conducted from 2014 to 2020 in 18 rural villages in Tianjin, China. A total of 2702 participants were included in the IMT analysis, and after excluding those with carotid plaques at baseline, 1595 participants were included in the plaque incidence analysis. Multivariate logistic regression was used to assess the relationship between the TyG index and outcomes. Subgroup analyses were based on significant indicators from the multivariate adjustment. Results: During the six-year follow-up, 551 new cases of carotid plaque were identified, with an incidence rate of 34.5%. Univariate analysis showed a significant association between the TyG index and increased plaque incidence. However, after adjusting for multiple confounders, the TyG index emerged as an independent predictor only for IMT increase. Each 1-unit increase in TyG was associated with a 49% increased risk (RR: 1.49; 95% CI: 1.05-2.13; P = 0.026), with this association being particularly strong in males, individuals aged ≥60 years, and those without hypertension. Conclusion: Results highlight the importance of incorporating the TyG index into cardiovascular risk assessments, especially for IMT changes in specific subpopulations. The study underscores the need for targeted prevention strategies in rural, low-education and low-income populations. Future research is needed to elucidate the potential interactions between the TyG index and other metabolic factors in ASCVD.
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