Evidence map›Paper›PMID 40546331›Full record

ArticleCurrent opinion in physiology2019

The Protective Role of Regular Aerobic Exercise on Vascular Function with Aging.

Daniel H Craighead, Kaitlin A Freeberg, Douglas R Seals

Abstract read
In one paragraph

Article in Current opinion in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel H CraigheadDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant Street, 354 UCB Clare 114, Boulder, CO 80309.
Kaitlin A FreebergDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant Street, 354 UCB Clare 114, Boulder, CO 80309.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant Street, 354 UCB Clare 114, Boulder, CO 80309.

Funding

American Heart Association-American Stroke Association 18POST33990034
6 · The paper itself

Abstract

Aging is the primary risk factor for cardiovascular diseases (CVD), the leading cause of death in developed and developing societies. Much of this age-associated increase in CVD risk is due to arterial dysfunction, characterized by stiffening of the large elastic arteries and endothelial dysfunction. Aerobic exercise is an evidence-based healthy lifestyle strategy for improving arterial function with aging, in part, by suppressing oxidative stress and chronic inflammation. Here, we summarize the effects exercise on arterial function and aging, highlighting recent advancements regarding estrogen-deficient postmenopausal women, cerebrovascular function and healthy lifestyle-inspired interventions that work through similar mechanisms as aerobic exercise.

Indexed as

Agingarterial stiffnessendothelial functionexercise

Identifiers

PMID40546331
PMCPMC12179772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.