ArticleBiological psychiatry global open science2025
Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation.
Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Sleep quality partially mediates the association between remnant cholesterol inflammatory index and depressive symptoms: multi-cohort analysis from cross-sectional and longitudinal cohorts.European archives of psychiatry and clinical neuroscience · 2026Article
- Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lipopolysaccharide-induced Neuroimmune Alteration and Memory Decline in Aging Mice: The Role of Augmented Cellular Senescence.Neurotoxicity research · 2026Article
- Immune dysregulation and neuroinflammation in bipolar disorder: Pathophysiological insights and therapeutic perspectives.Brain, behavior, & immunity - health · 2026Review
- Molecular Mechanisms of Phthalates in Depression: An Analysis Based on Network Toxicology and Molecular Docking.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuroinflammation is linked to the development of depression. Exposure to the proinflammatory endotoxin lipopolysaccharide (LPS) is associated with a depressive-like phenotype in rodents. However, acute LPS exposure may reflect sickness behavior, and thus the molecular mechanisms and neurobehavioral changes associated with chronic neuroinflammation warrant investigation. Methods: Using male Sprague Dawley rats ( Results: LPS administration induced systemic inflammation and subsequent neuroinflammation, as evidenced by increased circulating concentrations and regional expression of proinflammatory cytokines ( Conclusions: Taken together, our findings suggest that in LPS-induced systemic inflammation,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.