ArticleBiological psychiatry global open science2025
Divergent Longitudinal Trajectories and Neurotransmitter Associations of Striatal Subparcellation Spontaneous Activity in Major Depressive Disorder.
Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The striatum, which anatomically comprises the putamen, caudate, and nucleus accumbens (NAc), is a key region implicated in major depressive disorder (MDD). However, whether the abnormal spontaneous activity of these subparcellations exhibits universal or distinct characteristics remains unclear. Methods: In this study, we analyzed the amplitude of low-frequency fluctuations as an indicator of spontaneous activity from resting-state functional magnetic resonance imaging in 1832 individuals from 2 independent cohorts. Results: Patients with MDD demonstrated consistent hyperactivity in the putamen and NAc (Cohen's Conclusions: Spontaneous hyperactivity in the putamen and NAc are reproducible functional imaging markers of MDD. While the hyperactivity of the putamen was responsive to antidepressant treatment, the hyperactivity of the NAc was more trait like. In conclusion, our study revealed both common and divergent spontaneous activity characteristics of the striatum subparcellations in patients with MDD.
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