Evidence map›Paper›PMID 40546282›Full record

ArticleFrontiers in cellular and infection microbiology2025

Evolution of ceftazidime-avibactam resistance driven by variation in

Zeshi Liu, Jing Lei, Xue Zhang, Jian Yin, Yanping Zhang, Ke Lei, Yan Geng, Lingjuan Huang, Qiang Han, Aili He

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Phage and endolysin-based inhibition ofFrontiers in cellular and infection microbiology · 2026
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeshi LiuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jing LeiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xue ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jian YinDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yanping ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ke LeiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yan GengDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Lingjuan HuangGeriatrics Department, The First Affiliated Hospital of Xi'an Medical College, Xi'an, China.
Qiang HanDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Aili HeDepartment of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The emergence of Methods: The Results: KPC-190 exhibited a unique resistance profile: high-level CZA resistance (MIC >64 μg/mL) with reduced carbapenem MICs (imipenem MIC = 2 μg/mL). Enzyme kinetics revealed decreased Discussion: The KPC-190 variant underscores the adaptive evolution of

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeDrug CombinationsGenome, BacterialHumansKlebsiella InfectionsMicrobial Sensitivity TestsPlasmidsVirulenceWhole Genome SequencingAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-lactamase KPC-2, Klebsiella pneumoniaebeta-LactamasescarbapenemaseCeftazidimeDrug Combinationsantibiotic resistanceblaKPC variantsceftazidime-avibactamKlebsiella pneumoniaeKPC-190

Identifiers

PMID40546282
PMCPMC12179193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.