Evidence map›Paper›PMID 40546111›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.

Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The role of CD8Frontiers in immunology · 2026
    Pooled it
  2. Trial
  3. The oxidative stress paradigm in arbovirus infections: mechanisms and therapeutic insights.Redox report : communications in free radical research · 2026
    Review
  4. Review
  5. Mitochondrial dynamics and T cells immunity in cancer.Biochemistry and biophysics reports · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Ubiquitous Expression ofLife (Basel, Switzerland) · 2025
    Article
  16. Review
  17. Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  18. Terminally exhausted CD8Frontiers in immunology · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xu ChenStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Pei LinStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Ye LuStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Jiarong ZhengDepartment of Dentistry, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Yunfan LinStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Zihao ZhouStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Li CuiStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Xinyuan ZhaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.ORCID https://orcid.org/0000-0003-4770-8877

Funding

Guangdong Provincial Science and Technology Project Foundation 2022A0505050038National Natural Science Foundation of China 81901006 82372905Science and Technology Program of Guangzhou 2025A04J3464Science Research Cultivation Program of Stomatological Hospital, Southern Medical University PY2020002Scientific Research Talent Cultivation Project of Stomatological Hospital, Southern Medical University RC202005Young Top-notch Talent of Pearl River Talent Plan 0920220228
6 · The paper itself

Abstract

Mitochondria are integral to the regulation of CD8

Indexed as

CD8-Positive T-LymphocytesMitochondriaAnimalsHumansImmunotherapyMitochondrial DynamicsCD8⁺ T cellsimmunotherapymetabolic reprogrammingmitochondrial dynamicsT cell exhaustion

Identifiers

PMID40546111
PMCPMC12407280

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.