ArticleJournal of hypertension2025
LASSO logistic regression and cluster analysis in predicting adherence and drug patterns among new users of monotherapy for antihypertensive drugs.
Article in Journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveReal-world long-term adherence and drug utilization patterns are essential for hypertension management. However, the evidence was unclear. We aimed to construct adherence and drug patterns risk prediction models.
methodsWe designed a retrospective inception cohort study using pharmacy records from the University of Groningen IADB.nl dispensing database. Exposures were antihypertensive drug monotherapy including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium channel blockers, and thiazides. Primary outcomes included adherence rates and drug utilization patterns. Cluster analysis was performed to categorize patients with similar risk factors. Least Absolute Shrinkage and Selection Operator logistic regression was then employed to construct prediction models.
resultsThe adherence rate in the 1 st year to the 10 th year increased from 86.4% to 92.9%. Most monotherapies, middle and older age, with initial diabetes, asthma/ chronic-obstructive-pulmonary-disease drug, and without psycholeptics drug, first exposure prescription after 2000 promoted high adherence. Thiazides and being male were harmful to continuation and helpful to discontinuation, switching and adding on. Middle and older age promoted switching and adding on but impeded discontinuation. High adherence contributed to continuation, switching and adding on but impeded discontinuation. Thiazides were better for the short term use to achieve high adherence while calcium channel blockers in both short term and long term were better to achieve high adherence than beta-blockers.
conclusionsThe results highlighted key factors influencing medication adherence and treatment changes, emphasizing the need for personalized approaches to optimize patient care. Enhancing adherence and provide specific monotherapy for short term and long term plan were beneficial to better personalized treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.