Evidence map›Paper›PMID 40546090›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Tremor Asymmetry and the Development of Bilateral Phase-Specific Deep Brain Stimulation for Postural Tremor.

Shenghong He, Alceste Deli, Timothy O West, Fernando R Plazas, Alek Pogosyan, Christoph Wiest, Laura Wehmeyer, Fahd Baig, Francesca Morgante, Pablo Andrade and 7 more

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In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shenghong HeMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-5269-1902
Alceste DeliNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Timothy O WestMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Fernando R PlazasMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Alek PogosyanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Christoph WiestMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Laura WehmeyerMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Fahd BaigNeurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's, University of London, London, UK.
Francesca MorganteNeurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's, University of London, London, UK.ORCID https://orcid.org/0000-0002-9834-3639
Pablo AndradeDepartment of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
Michael G HartNeurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's, University of London, London, UK.
James J FitzGeraldNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
Erlick A PereiraNeurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's, University of London, London, UK.
Alexander L GreenNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Huiling TanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-8038-3029
Hayriye CagnanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Funding

Guarantors of BrainMedical Research Council MC_UU_00003/2Medical Research Council MR/R020418/1Medical Research Council MR/X023141/1
6 · The paper itself

Abstract

backgroundTremor phase-locked deep brain stimulation (DBS) has been shown to modulate symptom severity in postural tremor, including essential and dystonic tremor, with less energy than existing systems. Previous studies focused on unilateral stimulation; it remains unknown how tremor asymmetry interacts with stimulation in the context of bilateral phase-locked DBS.

methodsArchival limb acceleration from nine essential tremor patients was analyzed for asymmetries in tremor amplitude, frequency, and instability, and their relationship with continuous high-frequency DBS (cDBS). Bilateral phase-locked DBS was tested in one essential tremor and one dystonic tremor patient.

resultsPostural tremor is asymmetric, with larger tremor power linked to smaller amplitude and frequency instability in one hand. These asymmetries were significantly reduced during cDBS, with greater effects on larger amplitude tremors. Bilateral phasic DBS effects were also asymmetric.

conclusionsThis study enhances understanding of tremor asymmetry and its relationship with DBS, offering insights for patient-specific tremor treatments. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Deep Brain StimulationEssential TremorPostureTremorAgedFemaleHumansMaleMiddle Agedasymmetryinstabilityphase‐locked deep brain stimulationpostural tremor

Identifiers

PMID40546090
PMCPMC12485572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.