ArticleRenal failure2025
Reduced glutathione ameliorates sepsis-induced acute kidney injury in mouse model: involvement of cuproptosis.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review).International journal of molecular medicine · 2026Review
- Iron and Other Metal Ions in Human Health and Disease.MedComm · 2026Review
- Protective Effects of Lactobacillus rhamnosus GG Against Methotrexate-Induced Oxidative Renal Toxicity.Probiotics and antimicrobial proteins · 2026Article
- NIR-II Type I AIE Photosensitiser-Functionalized MOF-Cu Nanoplatform Promotes Ferroptosis and Cuproptosis for Antitumor Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Programmed cell death in kidney disease: integrated crosstalk among ferroptosis, pyroptosis, apoptosis, and cuproptosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Copper Metabolism-Related Cell Death in Kidney Diseases: Molecular Mechanisms, Disease-Specific Evidence, and Translational Implications.International journal of molecular sciences · 2026Review
- Non-apoptotic Regulated Cell Death Mechanisms in Sepsis and their Therapeutic Potential.Inflammation · 2026Review
- Silencing SLC31A1 attenuates high glucose plus copper-induced cuproptosis-like signaling, oxidative stress, and barrier dysfunction in human retinal microvascular endothelial cells.International journal of ophthalmology · 2026Article
- Copper-Induced Cell Death in Renal Diseases: Molecular Mechanisms and Therapeutic Implications.Drug design, development and therapy · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCuproptosis, a copper-induced form of programmed cell death, has been implicated in the pathogenesis of acute kidney injury (AKI) and sepsis. Reduced glutathione (GSH), a potent antioxidant, exhibits both anti-inflammatory and anti-oxidative properties. However, its potential role in modulating cuproptosis in AKI remains unexplored. This study investigates the effects of reduced GSH on cuproptosis in a sepsis-induced AKI mouse model.
methodsA sepsis mouse model was established
resultsReduced GSH treatment significantly improved survival rates and reduced bacterial loads in CLP mice. Additionally, reduced GSH attenuated inflammation and oxidative stress in the septic mice. It restored kidney function, decreased Cu levels in both urine and kidney tissues, and downregulated the expression of SLC31A1.
conclusionReduced GSH ameliorates sepsis-induced AKI by suppressing cuproptosis, offering potential therapeutic implications for the management of AKI in septic conditions.
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