ArticleAdvanced healthcare materials2025
Geometrically Controlled WNT Activation Drives Intestinal Morphogenesis.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biomimetic villi-crypt scaffold-on-chip with tunable mechanical properties for intestinal epithelium modeling.Materials today. Bio · 2026Article
- Geometrically Controlled WNT Activation Drives Intestinal Morphogenesis.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Morphogenesis is a multifaceted process that integrates biochemical signals with mechanical and architectural cues to drive tissue formation. Here, the modulation of WNT signaling and engineered microenvironments synergistically drive crypt-villus-like morphogenesis in colorectal carcinoma (Caco-2) cells. Fibroblast conditioned media induced WNT-dependent budding, confirmed via secretome profiling and WNT inhibition by Dickkopf-1 (DKK1). Direct modulation of WNT activity with agonist CHIR enhanced both epithelial budding and mucin 2 (MUC2) expression. To isolate the role of architecture in this process, fabricated gelatin methacrylate (GelMA) microwell arrays via digital light processing (DLP) printing enabled independent control of geometry and stiffness. Increased scaffold perimeter-to-area ratios promoted epithelial budding and MUC2 upregulation, even in the absence of exogenous WNT agonists. Disruption of myosin contractility abolished these effects, underscoring the importance of mechanotransduction in this process. These findings reveal that mechanical and architectural cues can independently orchestrate intestinal epithelial morphogenesis, offering new strategies for gut-mimetic culture systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.