ArticleDevelopmental medicine and child neurology2026
Motor performance and higher associative cortical networks in adolescents with neonatal hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia.
Article in Developmental medicine and child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Can functional magnetic resonance imaging provide new mechanistic and prognostic insight following neonatal hypoxic-ischaemic encephalopathy?Developmental medicine and child neurology · 2026Article
- Motor performance and higher associative cortical networks in adolescents with neonatal hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia.Developmental medicine and child neurology · 2026Article
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6 authors.
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Abstract
aimTo investigate the interaction between specialized motor networks and higher associative brain networks for motor performance in adolescents exposed to neonatal hypoxic-ischaemic encephalopathy (HIE).
methodIn this prospective, population-based cohort study of children (n = 66) with neonatal HIE treated with therapeutic hypothermia, follow-up was performed at age 10 to 12 years with resting-state functional magnetic resonance imaging and assessment of motor performance with the Movement Assessment Battery for Children, Second Edition (MABC-2). Brain-behaviour analysis was performed using statistical enrichment analysis and was compared to a control group (n = 43) using the McNemar test.
resultsThe final analysis included 35 children in the cohort with HIE (mean [SD] age at magnetic resonance imaging = 11 years 2 months [9 months]) and 21 children in the control cohort (10 years 2 months [8 months]). Motor performance (assessed with the MABC-2 total score and all subdomains) was reduced in the cohort with HIE compared to the controls and was significantly associated with several clusters of brain network connections. A significant group difference was found in the MABC-2 aiming and catching subdomain, which correlated with clusters of functional connectivity between the somatomotor and default mode networks in the cohort with HIE.
interpretationMotor impairment after therapeutic hypothermia-treated neonatal HIE is connected to alternative neural processing between motor and cognitive networks.
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