Evidence map›Paper›PMID 40545788›Full record

ArticleScandinavian journal of immunology2025

Impact of Obesity on Treatment Response in Patients With Chronic Inflammatory Disease Receiving Biologic Therapy: Secondary Analysis of the Prospective Multicentre BELIEVE Cohort Study.

Klara Riber Eggers, Karen Mai Møllegaard, Laura Gregersen, Silja Hvid Overgaard, Zainab Hikmat, Torkell Ellingsen, Jens Kjeldsen, Andreas Kristian Pedersen, Sofie Ronja Petersen, Mohamad Jawhara and 14 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Impact ofJournal of clinical medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Klara Riber EggersMolecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.
Karen Mai MøllegaardMolecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.
Laura GregersenMolecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.
Silja Hvid OvergaardMolecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.
Zainab HikmatMolecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.
Torkell EllingsenResearch Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
Jens KjeldsenResearch Unit of Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
Andreas Kristian PedersenDepartment of Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.
Sofie Ronja PetersenDepartment of Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.
Mohamad JawharaSection of Upper Benign and Hernia Surgery (G3), Department of Surgery, Odense University Hospital, Svendborg, Denmark.
Anders Bathum NexøeThe Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Anette BygumResearch Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
Christian Lodberg HvasDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Jens Frederik DahlerupDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Frederik Olof BergenheimThe Abdominal Center, Medical Section, Bispebjerg University Hospital, Copenhagen, Denmark.
Henning GlerupUniversity Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark.
Jacob Broder BrodersenThe Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Heidi Lausten MunkDepartment of Rheumatology, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0002-2212-6283
Natalia PedersenDepartment of Gastroenterology, Slagelse Regional Hospital, Slagelse, Denmark.
Ole Haagen NielsenDepartment of Gastroenterology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Karina Winther AndersenThe Faculty of Health Sciences, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Berit Lillenthal HeitmannResearch Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Robin ChristensenResearch Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
Vibeke AndersenMolecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.ORCID https://orcid.org/0000-0002-0127-2863

Funding

HORIZON EUROPE Reforming and enhancing the European Research and Innovation system 733100Knud og Edith Eriksens MindefondOak Foundation OCAY-18-774-OFIL
6 · The paper itself

Abstract

Biological therapy is used to treat chronic inflammatory diseases (CIDs); however, up to 50% of patients fail to achieve an adequate clinical response. This study aimed to access the impact of obesity on clinical treatment response in CID patients after 14-16 weeks of biological therapy. This multicentre prospective cohort study enrolled 233 adults between 2017 and 2020 diagnosed with Crohn disease, ulcerative colitis (UC), rheumatoid arthritis, axial spondyloarthritis (PsA), psoriatic arthritis or psoriasis scheduled for biologic therapy. The main analysis population included patients with BMI data before treatment initiation, categorising patients as either obese (BMI ≥ 30 kg/m

Indexed as

Biological ProductsBiological TherapyInflammationObesityAdultAgedArthritis, PsoriaticArthritis, RheumatoidBody Mass IndexChronic DiseaseColitis, UlcerativeCrohn DiseaseFemaleHumansMaleMiddle AgedBiological Productsautoimmune diseaseaxial spondyloarthritisbiological therapybody mass indexCrohn diseasepsoriasispsoriatic arthritisrheumatoid arthritistreatment outcomeulcerative colitis

Identifiers

PMID40545788
PMCPMC12183491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.