SynthesisJournal of clinical laboratory analysis2025
The Role of Interleukin-23 and Interleukin-17 in Peri-Implant Crevicular Fluid of Subjects With Peri-Implant Disease: A Systematic Review.
Synthesis in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Early peri-implant crevicular fluid interleukin-1β as a potential predictor of peri-implant diseases: a 12-month prospective study.Frontiers in medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActivation of the IL-23/IL-17 cytokine axis could trigger peri-implant bone loss. The aim of this review was to analyze whether in people with peri-implantitis (PI) and peri-implant mucositis (PM) the concentrations of the interleukin-23 and interleukin-17 in peri-implant crevicular fluid (PICF) are elevated compared to people with healthy dental implants (HDI). METHODOLOGY: The protocol of this study was registered in OSF (ID: 10.17605/OSF.IO/U8NBQ) and followed PRISMA guidelines. PECO criteria were used to formulate the research question. A search strategy was performed using PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar until November 15, 2024. A rigorous evaluation was performed, and the JBI tool was used to assess the quality of the cross-sectional and case-control studies.
resultsFourteen observational studies were included in this study, with a total of 587 participants carrying 601 dental implants. The control group was represented by 252 healthy implants, while the exposure group was represented by 113 implants with PM and 236 implants with peri-implantitis. The age range of the subjects varied from 40.8 to 68.6 years, with a mean age ± standard deviation of 53.9 ± 9.9 years. The concentration of the IL-23/IL-17 cytokine axis and isoforms (IL-17E and IL-17F) was higher in subjects with peri-implant disease compared to the healthy population. Most of the studies (92.8%) showed moderate quality.
conclusionsThe concentrations of cytokines IL-23, IL-17, and IL-17E in PICF were higher in PI-affected dental implants, followed by PM-affected dental implants compared to HDI.
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