Evidence map›Paper›PMID 40545713›Full record

ArticleOral diseases2025

Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study.

Luciano Miziara, Marcio Augusto de Oliveira, Debora Macedo, Ligia Pierrotti, Fabiana Agena, Elias David-Neto, Aluísio Cotrim Segurado, Rodrigo Zerbinati, Marina Gallottini, Paulo Braz-Silva and 1 more

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Article in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Luciano MiziaraPostgraduate Program in Dentistry, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
Marcio Augusto de OliveiraBiostatistician, São Paulo, Brazil.
Debora MacedoPostgraduate Program in Dentistry, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
Ligia PierrottiNephrology Service, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Fabiana AgenaNephrology Service, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-4526-4857
Elias David-NetoNephrology Service, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Aluísio Cotrim SeguradoInfectious Diseases Division, Medical School, University of São Paulo, São Paulo, Brazil.
Rodrigo ZerbinatiLaboratory of Virology (LIM-52), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil.
Marina GallottiniDepartment of Stomatology, School of Dentistry, University of Sao Paulo, São Paulo, Brazil.
Paulo Braz-SilvaLaboratory of Virology (LIM-52), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1842-9521
Fabiana MartinsPostgraduate Program in Dentistry, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4352-7959

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo
6 · The paper itself

Abstract

backgroundKidney transplant recipients (KTRs) experience immune modulation, which may lead to graft rejection and other adverse outcomes. Although serum cytokines are well-established systemic immune markers, the role of salivary biomarkers has never been reported in the literature.

objectiveTo investigate salivary and serum cytokine levels in KTRs and their correlations with clinical outcomes over time. MATERIALS AND

methodsWe evaluated the same group of 38 KTRs at T1 (< 6 months post-transplantation) and T2 (> 6 months post-transplantation). Samples were analysed with Human 6-Plex Cytokine Panel (Luminex) and clinical data were collected from medical records. Statistical analyses included Wilcoxon tests, Fisher's exact tests, Spearman's correlation, and Benjamini-Hochberg procedure for multiple comparisons (p < 0.05 significant).

resultsSerum cytokines showed lower IFN-γ levels in cardiac events and associations of TNF-α, IL-8, and IL-10 with cytomegalovirus (CMV), BK polyomavirus (BKPyV) viremia and anaemia. Salivary cytokines showed distinct profiles, with elevated levels of TNF-α in anaemia and IL-8 in patients with diarrhoea. Those not experiencing acute rejection in both cases showed reduced salivary IL-8 levels.

conclusionsIntegrating serum and salivary measurements highlighted the potential of salivary biomarkers, particularly TNF-α and IL-8, in complementing traditional blood-based assays and other invasive monitoring methods in kidney transplantation.

Indexed as

CytokinesKidney TransplantationSalivaAdultAgedBiomarkersFemaleGraft RejectionHumansInterferon-gammaInterleukin-10Interleukin-8MaleMiddle AgedProspective StudiesTumor Necrosis Factor-alphaBiomarkersCytokinesInterferon-gammaInterleukin-10Interleukin-8Tumor Necrosis Factor-alphaacute rejectionclinical outcomescytokineskidney transplantationsaliva

Identifiers

PMID40545713
PMCPMC12989047

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