Evidence map›Paper›PMID 40545505›Full record

ArticleScience China. Life sciences2025

Insights into tissue- and cell type-specific effects of Grb10 on pig skeletal muscle growth by multi-omics analysis.

Meng Li, Huan Liu, Tingting Lu, Suchen Li, Xinchen Zhou, Hui Miao, Yuelang Zhang, Chen Peng, Kaiyu Chen, Jiayi He and 3 more

Abstract read
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Article in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Meng LiHainan Institute, Zhejiang University, Sanya, 572000, China.
Huan LiuHainan Institute, Zhejiang University, Sanya, 572000, China.
Tingting LuCollege of Animal Science, Zhejiang University, Hangzhou, 310058, China.
Suchen LiCollege of Animal Science, Zhejiang University, Hangzhou, 310058, China.
Xinchen ZhouHainan Institute, Zhejiang University, Sanya, 572000, China.
Hui MiaoHainan Institute, Zhejiang University, Sanya, 572000, China.
Yuelang ZhangHainan Institute, Zhejiang University, Sanya, 572000, China.
Chen PengHainan Institute, Zhejiang University, Sanya, 572000, China.
Kaiyu ChenHainan Institute, Zhejiang University, Sanya, 572000, China.
Jiayi HeHainan Institute, Zhejiang University, Sanya, 572000, China.
Yulong YinYuelushan Laboratory, Changsha, 410128, China.
Pengju ZhaoHainan Institute, Zhejiang University, Sanya, 572000, China. zhaopengju2014@gmail.com.
Xinyan HanHainan Institute, Zhejiang University, Sanya, 572000, China. xyhan@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Domestic pigs are shaped by artificial and natural selection into obese and lean types that are closely related to muscle tissue. However, the key genes and regulatory mechanisms behind these developments remain largely unknown. Here, we pinpoint GRB10 specificity in muscle tissue and cells between obese and lean pigs by combining genomics, transcriptomics, epigenomics, and single-cell transcriptomics. GRB10 shows notable differences in divergent selection on haplotype blocks and expression levels between obese and lean pig breeds, with its expression profiles varying significantly by tissue and development stage. Notably, we identify a muscle-specific promoter of GRB10 and its transcription factor KLF15. This TF-promoter binding is verified by dual luciferase and chromatin immunoprecipitation (ChIP) assays, and is suggested to be conserved in humans. Single-nucleus RNA sequencing further highlights differential expression patterns of GRB10 between obese and lean pig breeds across various cell types. Type IIa myonuclei and TTN

Indexed as

GRB10 Adaptor ProteinMuscle DevelopmentMuscle, SkeletalAnimalsGene Expression ProfilingGenomicsMultiomicsObesityOrgan SpecificityPromoter Regions, GeneticSwineTranscriptomeGRB10 Adaptor ProteinGRB10KLF15multi-omicsmuscle growthmuscle-specific promotersingle-nucleus RNA sequencing

Identifiers

PMID40545505

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.