Evidence map›Paper›PMID 40545466›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2025

[Effect of removing microglia from spinal cord on nerve repair after spinal cord injury in mice].

Qi Jiang, Chao Qi, Yuerong Sun, Shiyuan Xue, Xinyi Wei, Haitao Fu

Abstract readEnglish Abstract
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Mechanisms of Piezo1-mediated microglial ferroptosis in inhibiting spinal cord injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  2. [Effect of composite graphene-protein hydrogels on neural regeneration after spinal cord injury in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qi JiangQingdao Medical College, Qingdao University, Qingdao Shandong, 266073, P. R. China.
Chao QiDepartment of Sports Medicine, Affiliated Hospital of Qingdao University, Qingdao Shandong, 266103, P. R. China.
Yuerong SunDepartment of Sports Medicine, Affiliated Hospital of Qingdao University, Qingdao Shandong, 266103, P. R. China.
Shiyuan XueQingdao Medical College, Qingdao University, Qingdao Shandong, 266073, P. R. China.
Xinyi WeiQingdao Medical College, Qingdao University, Qingdao Shandong, 266073, P. R. China.
Haitao FuDepartment of Sports Medicine, Affiliated Hospital of Qingdao University, Qingdao Shandong, 266103, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effects of removing microglia from spinal cord on nerve repair and functional recovery after spinal cord injury (SCI) in mice. Methods: Thirty-nine 6-week-old female C57BL/6 mice were randomly divided into control group ( Results: All mice survived until the end of the experiment. Immunofluorescence staining revealed that the microglia in the spinal cord of the PLX3397+SCI group decreased by more than 95% compared to the control group after 14 days of continuous feeding with PLX3397 ( Conclusion: The removal of microglia in the spinal cord aggravate the tissue damage after SCI and affecte the recovery of motor function in mice, suggesting that microglia played a neuroprotective role in SCI.

Indexed as

AminopyridinesMicrogliaNerve RegenerationPyrrolesSpinal CordSpinal Cord InjuriesAnimalsCalcium-Binding ProteinsDisease Models, AnimalFemaleGlial Fibrillary Acidic ProteinMiceMice, Inbred C57BLMicrofilament ProteinsReceptors, Granulocyte-Macrophage Colony-Stimulating FactorRecovery of FunctionAif1 protein, mouseAminopyridinesCalcium-Binding ProteinsGlial Fibrillary Acidic ProteinMicrofilament ProteinspexidartinibPyrrolesReceptors, Granulocyte-Macrophage Colony-Stimulating FactorMicrogliamousenerve injuryspinal cord injury

Identifiers

PMID40545466
PMCPMC12179246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.