Evidence map›Paper›PMID 40545444›Full record

ArticleChembiochem : a European journal of chemical biology2025

2-Oxoglutarate Analog-Based Biomolecular Tools for Exploring Structure-Activity Relationships in Nonheme Iron Enzymes.

Peter Windsor, Sourav Chatterjee, Anoop Rama Damodaran, Ambika Bhagi-Damodaran

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter WindsorDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, 55455, USA.
Sourav ChatterjeeDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, 55455, USA.
Anoop Rama DamodaranDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, 55455, USA.ORCID https://orcid.org/0000-0002-2094-9956
Ambika Bhagi-DamodaranDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, 55455, USA.ORCID https://orcid.org/0000-0002-4901-074X

Funding

Decoding and Rewiring Enzymatic Redox Signal Transduction PathwaysR35GM138277 · NIGMS · UNIVERSITY OF MINNESOTA · PI Ambika Bhagi · 2020 to 2026
$2.6M
NIGMS NIH HHS R35 GM138277NIH HHS R35GM138277NSF 2046527
6 · The paper itself

Abstract

2-oxoglutarate (2OG)-dependent nonheme iron (NHFe) enzymes constitute a family of enzymes that use 2OG and oxygen to hydroxylate unactivated C(sp

Indexed as

Enzyme InhibitorsHypoxia-Inducible Factor-Proline DioxygenasesKetoglutaric AcidsCatalytic DomainHumansKineticsMolecular StructureStructure-Activity RelationshipEGLN1 protein, humanEnzyme InhibitorsHypoxia-Inducible Factor-Proline DioxygenasesKetoglutaric Acids2‐oxoglutaratesanalogsnonheme ironsprolyl hydroxylase domain 2structure–activity relationships

Identifiers

PMID40545444
PMCPMC12432536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.