ArticleMacromolecular bioscience2025
Amphiphilic Poly(γ-glutamic acid) Derivatives for Delivering Doxorubicin in Cancer Cells.
Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Amphiphilic Poly(γ-glutamic acid) Derivatives for Delivering Doxorubicin in Cancer Cells.Macromolecular bioscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
One of the most limiting factors in cancer treatment is the difficulty of delivering anticancer agents effectively to tumor sites. To overcome this challenge, this research focuses on developing a carrier that has been modified to possess amphiphilic properties while remaining biodegradable and biocompatible. Amphiphilic esters derived from poly(γ-glutamic acid) by modifying the carboxylate side groups with 4-phenyl-butyl bromide were prepared. These copolymers self-assembled into nanoparticles via nanoprecipitation. The cytocompatibility of the nanoparticles was assessed through lactate dehydrogenase release and metabolic activity of U-87 glioma cells. Fluorescein isothiocyanate labeling demonstrated effective cellular uptake of nanoparticles. These nanoparticles were further decorated with polyethylene glycol (PEG) and a PEG-folic acid conjugate (FA-PEG-NH
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.