Evidence map›Paper›PMID 40545148›Full record

ArticleDiabetes research and clinical practice2025

Associations of age at T2D detection with hemoglobin A1c in a national inception cohort of U.S. Veterans with diabetes.

Sanja Avramovic, Xumin Li, Daniel A Enquobahrie, Mark D Schwartz, Anna Korpak, Edward J Boyko, Pandora L Wander

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In one paragraph

Article in Diabetes research and clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sanja AvramovicVeterans Affairs New York Harbor Healthcare System, New York, NY, USA; Health Administration and Policy, George Mason University, Fairfax, VA, USA.
Xumin LiVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Mark D SchwartzVeterans Affairs New York Harbor Healthcare System, New York, NY, USA; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA.
Anna KorpakVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Edward J BoykoVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Pandora L WanderVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: lwander@u.washington.edu.

Funding

NCCDPHP CDC HHS U01 DP006299
6 · The paper itself

Abstract

objectiveTo investigate associations of age at type 2 diabetes (T2D) detection with HbA1c. RESEARCH DESIGN AND

methodsWe examined associations of early-onset T2D (age of detection 20-39 years) and age at T2D detection with HbA1c in Veterans with incident T2D (1/1/2008-12/31/2016; n = 851,302).

resultsAbout 3 % (n = 22,649) of men and 11 % (n = 5,117) of women had early-onset T2D. Compared to men with later-onset T2D, men with early-onset T2D had a 0.71 (95 %CI 0.69,0.73) greater HbA1c after detection, a 0.78 (95 %CI 0.77,0.80) greater mean HbA1c, and a 0.05 (95 %CI 0.04,0.05) greater coefficient of variation (CV). Each 10-year decrease in age was associated with greater HbA1c after detection, mean HbA1c, and HbA1c CV (β 0.21 (95 %CI 0.21,0.21), 0.25 (95 %CI 0.24,0.25), 0.02 (95 %CI 0.02,0.02), respectively). In women, early-onset T2D was associated with a 0.14 (95 %CI -0.18,-0.10) lower HbA1c after detection and a 0.01 greater CV (95 %CI 0.01,0.01). Each ten-year decrease in age was associated with greater mean HbA1c and CV (β 0.09 (95 %CI 0.08,0.10); 0.01 (95 %CI 0.01,0.01), respectively).

conclusionAmong male Veterans, early-onset T2D was associated with greater HbA1c and greater HbA1c variability. Similar results were seen among women but of lesser magnitude. Longitudinal research examining sex-specific impacts of early-onset T2D on clinical course is needed.

Indexed as

Diabetes Mellitus, Type 2Glycated HemoglobinVeteransAdultAgedAge FactorsAge of OnsetCohort StudiesFemaleHumansMaleMiddle AgedUnited StatesYoung AdultGlycated Hemoglobinhemoglobin A1c protein, humanEarly-onsetEpidemiologyHbA1c

Identifiers

PMID40545148
PMCPMC12317824

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LicenceTDM
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.