Evidence map›Paper›PMID 40545018›Full record

ArticleAmerican journal of ophthalmology2025

Association Between Optic Nerve Head Prelaminar Schisis and Visual Field Progression in Glaucoma.

Ghazaleh Soltani, Takashi Nishida, Sasan Moghimi, Elaine Tran, Maya Yamane, Christopher Girkin, Linda M Zangwill, Robert N Weinreb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ghazaleh SoltaniFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Takashi NishidaFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Sasan MoghimiFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Elaine TranFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Maya YamaneFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Christopher GirkinFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Linda M ZangwillFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.
Robert N WeinrebFrom the Viterbi Family Department of Ophthalmology (G.S., T.N., S.M., E.T., M.Y., C.G., L.M.Z., and R.N.W.), Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA. Electronic address: rweinreb@ucsd.edu.

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Monitoring of Glaucoma Patients in Advanced DiseaseR01EY034148 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sasan Moghimi Araghi · 2022 to 2026
$2.5M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS R01 EY034148
6 · The paper itself

Abstract

purposeTo investigate the association between baseline optic nerve head prelaminar schisis and the rates of visual field mean deviation (VF MD) slopes in glaucoma.

designRetrospective clinical cohort study.

methodsThis study included 563 eyes (446 with primary open-angle glaucoma and 117 glaucoma suspect eyes) from 332 patients. Two independent graders evaluated the baseline presence and severity of prelaminar schisis using optical coherence tomography radial scans. The severity was graded on a four-point ordinal scale: 0 (none), 1 (mild), 2 (moderate), and 3 (severe). The interrater reliability was assessed using weighted kappa. Two linear mixed-effect models were employed to assess the association between the presence of schisis (model 1) and schisis severity (model 2) with VF MD slopes, while adjusting for relevant demographic and ocular characteristics.

resultsPrelaminar optic nerve head schisis was observed in 258 eyes (45.8%). Among these, grade 1 was identified in 36 eyes (14.0%), grade 2 in 181 eyes (70.2%), and grade 3 in 41 eyes (15.9%). The weighted kappa was 0.66. In multivariable models, the presence of schisis was associated with a faster VF MD slope (-0.22 dB/y; 95% confidence interval [CI]: -0.30, -0.13 P ≤ .001). Compared to eyes without prelaminar schisis (grade 0), those with schisis were associated with faster VF MD slopes. This was more significant with grade 3 (-0.40 dB/y; 95% CI: -0.63, -0.18; P < .001) than with grade 1 (-0.18 dB/y; 95% CI: -0.34, -0.03; P = .023), or grade 2 (-0.18 dB/y; 95% CI: -0.26, -0.09; P < .001). Age and baseline VF MD were also independently associated with VF progression in both models.

conclusionsThe presence and severity of severe prelaminar schisis were associated with faster VF progression, suggesting its potential as a biomarker to identify patients at higher risk of progression and to guide clinical management in glaucoma.

Indexed as

Glaucoma, Open-AngleOptic DiskOptic Nerve DiseasesVision DisordersVisual FieldsAgedDisease ProgressionFemaleHumansIntraocular PressureMaleMiddle AgedNerve FibersRetrospective StudiesTomography, Optical CoherenceVisual Field Tests

Identifiers

PMID40545018
PMCPMC13592681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.