Evidence map›Paper›PMID 40544955›Full record

ArticleContemporary clinical trials2025

Conducting an implementation intervention study with American Indian and Alaska Native communities: Methodological considerations.

Margaret M Paschen-Wolff, Aimee N C Campbell, Ángel Vásquez, Jill Kessler, Kelley Jansen, Catherine P Arnatt, Carmen Rosa, Hanna M Hebden, Sandra Radin, Antony Stately and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04958798 (Culturally Centering Medications for Opioid Use Disorder With American Indian and Alaska), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04958798 nacompletednot on this map

Culturally Centering Medications for Opioid Use Disorder With American Indian and Alaska

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2021 to 2025Enrolled2,059ConditionsOpioid-use DisorderArmsCulturally Centered MOUD Implementation Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Exploring the use of telemedicine to expand addiction and recovery resources in Great Plains Tribal Communities.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Margaret M Paschen-WolffColumbia University Irving Medical Center, Department of Psychiatry and New York State Psychiatric Institute, Division on Substance Use Disorders, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA. Electronic address: margaret.paschen-wolff@nyspi.columbia.edu.
Aimee N C CampbellColumbia University Irving Medical Center, Department of Psychiatry and New York State Psychiatric Institute, Division on Substance Use Disorders, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA.
Ángel VásquezUniversity of New Mexico, Center on Alcohol, Substance Use and Addictions (CASAA), 2650 Yale Blvd SE, Albuquerque, NM, 87106, USA.
Jill KesslerMissouri Breaks Industries Research, Inc, 505 South Willow Street, P.O. Box 1824, Eagle Butte, SD 57625, USA.
Kelley JansenUniversity of Alaska Fairbanks, Center for Alaska Native Health Research, 2141 Koyukuk Dr., Fairbanks, AK 99775, USA.
Catherine P ArnattSouthcentral Foundation, Anchorage Native Primary Care Center, 4320 Diplomacy Dr., Anchorage, AK 99508, USA.
Carmen RosaNational Institute of Health, National Institute on Drug Abuse, Landsdown St., North Bethesda, MD 20852, USA.
Hanna M HebdenUniversity of New Mexico, Center on Alcohol, Substance Use and Addictions (CASAA), 2650 Yale Blvd SE, Albuquerque, NM, 87106, USA; University of New Mexico, Department of Psychology, Logan Hall, MSC03-2220, 1 University of New Mexico, Albuquerque, NM 87131, USA.
Sandra RadinUniversity of Washington, Addictions, Drug, and Alcohol Institute, 1107 NE 45th Street, Seattle, WA 98105, USA.
Antony StatelyNative American Community Clinic, 1213 E Franklin Ave., Minneapolis, MN 55404, USA.
Jennifer ShawUniversity of Alaska Fairbanks, Center for Alaska Native Health Research, 2141 Koyukuk Dr., Fairbanks, AK 99775, USA.
Favian KennedyAnpetu Luta Otipi, Oglala Sioux Tribe, N Rte Rd, Kyle, SD 57752, USA.
Abigail G MatthewsThe Emmes Company, 401 N Washington St., Suite # 700, Rockville, MD 20850, USA.
Kamilla L VennerUniversity of New Mexico, Center on Alcohol, Substance Use and Addictions (CASAA), 2650 Yale Blvd SE, Albuquerque, NM, 87106, USA; University of New Mexico, Department of Psychology, Logan Hall, MSC03-2220, 1 University of New Mexico, Albuquerque, NM 87131, USA.

Funding

Project-003UG1DA013035 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aimee N Campbell, Jennifer McNeely · 2015 to 2026
$130.3M
Clinical Trials Network: Pacific Northwest Node (CTN-0082, -0131, -0139 and dissemination library)UG1DA013714 · NIDA · UNIVERSITY OF WASHINGTON · PI Mary Akiko Hatch, John M. Roll · 2015 to 2026
$19.8M
Southwest Clinical Trials Node: Clinical Research and Practice to Address Substance Use in Diverse, Rural, and Underserved PopulationsUG1DA049468 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MARIA ADELA GRANDO, Kimberly Page · 2019 to 2026
$12.5M
Alcohol Research Training: Methods & MechanismsT32AA018108 · NIAAA · UNIVERSITY OF NEW MEXICO · PI Katie A Witkiewitz · 2010 to 2026
$5.6M
NIAAA NIH HHS T32 AA018108NIDA NIH HHS UG1 DA013035NIDA NIH HHS UG1 DA013714NIDA NIH HHS UG1 DA049468
6 · The paper itself

Abstract

backgroundIncorporating American Indian and Alaska Native (AI/AN) traditional practices and knowledge into healthcare can support AI/AN health. Drug overdose deaths disproportionately impact AI/AN communities due to colonization, genocide, historical trauma, discriminatory policies, and under-resourced healthcare. Medications for opioid use disorder (MOUD; e.g., buprenorphine, methadone, naltrexone) are considered the most effective treatment for reducing mortality. Integrating AI/AN cultural practices with MOUD may increase acceptability and uptake of MOUD within AI/AN communities.

methodsNational Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) Protocol #0096 (Tribal MOUD) is a two-phase community-based participatory research (CBPR) trial to develop and evaluate an implementation intervention to culturally center MOUD delivery in AI/AN communities (N = 4 sites). A Collaborative Board (CB) guided intervention development (Phase I completed). A stepped wedge design (two sites/step) allows intervention implementation at all sites and improvements across sites (Phase II ongoing). The primary implementation outcome is the number of consumers with OUD who initiate MOUD in the six months pre-intervention vs. implementation periods; secondary outcomes are MOUD screening and retention (de-identified electronic medical record data). Additional data include organizational predictors (staff surveys) and moderators (consumer assessments) of implementation outcomes; and MOUD intervention acceptability (staff/consumer qualitative interviews).

conclusionsThis is the first study to develop and evaluate an implementation intervention to culturally center MOUD delivery in AI/AN communities. Implementation science and CBPR are complimentary for co-developing strategies with AI/AN communities to integrate Indigenous and Western best practices, which may ultimately reduce opioid-related mortality among AI/AN peoples and enhance Indigenous community wellness. Clinical Trials NCT Registration Number:NCT04958798.

Indexed as

American Indian or Alaska NativeOpiate Substitution TreatmentOpioid-Related DisordersBuprenorphineClinical Trials as TopicCommunity-Based Participatory ResearchCulturally Competent CareHumansMethadoneMulticenter Studies as TopicResearch DesignUnited StatesBuprenorphineMethadoneAmerican Indian/Alaska Native communitiesCommunity based participatory researchCulturally centered treatmentImplementation scienceMedications for opioid use disorder

Identifiers

PMID40544955
PMCPMC12282509

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.