ArticleJournal of colloid and interface science2025
Evaluating the impact of chaotropic salts on protein corona formation on polyethylene glycol-b-polylactic acid polymersomes.
Article in Journal of colloid and interface science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Polymersomes (PS) are a class of hollow polymeric nanoparticle vesicles made of amphiphilic block co-polymers that self-assemble via hydrophobic interactions. One of the significant unsung challenges for their translation is the uncontrolled formation of the protein corona, which can influence PS biodistribution, cellular uptake, and immune recognition. Despite the major benefits associated with PS, no studies have yet explored engineering their protein corona. Evidence suggests that the confirmation of polyethylene glycol (PEG) chains, which can vary in response to Hofmeister series salts, can affect protein corona composition. Here, we investigated the impact of different Hofmeister series salt ions, focusing on increasing chaotropic salts [NaCl (Na
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