ArticleJournal of pediatric gastroenterology and nutrition2025
The prevalence and predictive factors of overlapping disorders of gut-brain interaction and celiac disease in children.
Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Postsurgical Disorders of the Gut-Brain Axis and the Need for Multidisciplinary Treatment Approach: Authors' Reply.Neurogastroenterology and motility · 2026Article
- Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Review
- The prevalence and predictive factors of overlapping disorders of gut-brain interaction and celiac disease in children.Journal of pediatric gastroenterology and nutrition · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
objectivesDisorders of gut-brain interaction (DGBI) are increasing in prevalence; however, diagnosis remains challenging in the setting of organic diseases. While adult studies have shown overlap between DGBI and celiac disease (CeD), no United States studies have assessed DGBI prevalence using Rome IV criteria in pediatric CeD. This study aims to report DGBI prevalence in pediatric CeD patients adherent to gluten-free diet (GFD) with declining serologies and identify common DGBI subtypes and predictive factors for developing DGBI.
methodsSingle-center, retrospective study of children (4-21 years old) with biopsy-proven CeD who were evaluated for DGBI based on Rome IV criteria. Patients who were adherent to a GFD, demonstrated tissue transglutaminase immunoglobulin A (TTG IgA) decline, and had at least one visit 9-24-months after diagnosis with a pediatric gastroenterologist were assessed for the presence or absence of gastrointestinal symptoms at all subsequent follow-up visits. Predictive factors associated with DGBI diagnosis were evaluated.
resultsOf the 191 pediatric patients included, 43% (n = 83) met Rome IV DGBI diagnostic criteria. Functional constipation (27/83, 33%) and functional abdominal pain (24/83, 29%) were the most common DGBI. Abdominal pain, constipation, and vomiting at initial presentation as well as comorbid joint hypermobility, headaches, and chronic musculoskeletal pain increased risk of developing DGBI after serological decline.
conclusionsDGBI are common in pediatric CeD patients adherent to a GFD with declining TTG IgA. Clinicians should have a high index of suspicion for DGBI in CeD patients with persistent symptoms despite strict GFD adherence to facilitate diagnosis and management.
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