Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Alba Hernangomez-LaderasDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID http://orcid.org/0009-0001-9948-5399
Ariadna Cilleros-PortetDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0001-7564-6840
Mikel de la Peña-SanzDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.
Sergi MaríDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0003-2023-195X
Corina LesseurDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0001-6744-6750
Itziar González-MoroDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0002-6504-4931
Bárbara P González-GarcíaDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0002-9287-6047
Jia ChenDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Iraia García-SantistebanDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0002-7912-385X
Carmen J MarsitGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-4566-150X
Jose Ramon BilbaoDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0002-3176-501X
Nora Fernandez-JimenezDepartment of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID https://orcid.org/0000-0001-6307-0880
Funding
Characterizing the functional genomic atlas of human placenta and unveiling the prenatal programming of early-life developmentR01HD108310 · NICHD · EMORY UNIVERSITY · PI Jia Chen, Carmen Joseph Marsit · 2023 to 2026
$2.8M
Enriching the Rhode Island Child Health StudyU24ES028507 · NIEHS · EMORY UNIVERSITY · PI MARSIT, CARMEN JOSEPH, STROUD, LAURA R · 2023 to 2025
$1.0M
Integrative analysis of human placental epi/genome in relation to fetal growthR00HD097286 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LESSEUR PEREZ, CORINA · 2021 to 2023
$732k
Environmental influences and function of cytosine modification in human placentaR21ES028226 · NIEHS · EMORY UNIVERSITY · PI MARSIT, CARMEN JOSEPH · 2017 to 2018
$429k
ESF Investing in Your FutureHealth Department of the Basque Country 2020111043Health Department of the Basque Country 2024111079Instituto de Salud Carlos III (ISCIII) PI21/01491MCIN/AEI/10.13039/501100011033 PID2019-106382RB-I00MCIN/AEI/10.13039/501100011033 PRE2020-096742Mexican National Council for Science and Technology 2021-000007-01EXTF-00209NICHD NIH HHS R00 HD097286NICHD NIH HHS R00HD097286NICHD NIH HHS R01 HD108310NICHD NIH HHS R01HD108310NIEHS NIH HHS R21 ES028226NIEHS NIH HHS U24 ES028507NIEHS NIH HHS U24ES028507University of the Basque Country COLAB22/01University of the Basque Country EHU-G24/06U.S. National Institutes of Health
6 · The paper itself
Abstract
objectivesSeveral studies suggest that the first immunogenic insult in celiac disease (CeD) could occur during fetal development. The placenta is a key organ that could link the environment with the genome and future outcomes, including CeD. Our objective is to determine the involvement of placental DNA methylation (DNAm) as potential mediator of the genetic susceptibility to CeD.
methodsWe used Summary-data-based Mendelian Randomization to infer what part of the susceptibility to CeD acts through DNAm in placenta or peripheral blood. We interrogated whether DNAm of the CpGs identified correlated with the expression of adjacent genes in the same tissues, and repeated the procedure only in cases and controls carrying the HLA-DQ2 risk haplotype.
resultsWe identified 248 and 215 CpGs associated with CeD in placenta and blood, respectively. Among the former, the DNAm of seven CpGs correlated with the placental expression of ZFP57. In contrast, in the latter group, the most represented gene was RNF5, with DNAm of 11 CpGs correlating with its expression in blood. In HLA-DQ2 positive individuals, we observed a decrease of placental CpGs associated with CeD, with a remarkable exception in chromosome 2, close to AHSA2. In blood, we identified 44 CpGs associated with CeD in the HLA region, with HLA-DPA1 showing the largest number of DNAm-expression associations.
conclusionsOur results suggest that placenta does not seem to be a crucial effector in CeD, and show potentially causal relationships between blood DNAm and CeD, with independent signals in the HLA, and particularly in the HLA-DPA1 gene.
Indexed as
Celiac DiseaseDNA MethylationGenetic Predisposition to DiseasePlacentaCase-Control StudiesCpG IslandsFemaleHLA-DQ AntigensHumansMendelian Randomization AnalysisPregnancyHLA-DQ2 antigenHLA-DQ Antigenscomplex diseasesgene expressiongenetic predispositionHLA region
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Impact of placental and peripheral blood DNA methylation on celiac disease susceptibility. · full record | OpenQuestion