Evidence map›Paper›PMID 40544272›Full record

ArticleBMC oral health2025

How does medication-related osteonecrosis of the jaw (MRONJ) influence the health-related quality of life after surgery?

Oliver Bissinger, Josefa Greiser, Elisabeth Maier, Philipp Ehrmann, Tamara Kakoschke, Klaus-Dietrich Wolff, Carolin Götz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oliver BissingerDepartment of Oral and Maxillofacial Surgery, Medical University of Innsbruck, Anichstr. 35, Innsbruck, 6020, Austria.
Josefa GreiserDepartment of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany.
Elisabeth MaierDepartment of Oral and Maxillofacial Surgery, Medical University of Innsbruck, Anichstr. 35, Innsbruck, 6020, Austria. Elisabeth.maier@i-med.ac.at.
Philipp EhrmannDepartment of Oral and Maxillofacial Surgery, Medical University of Innsbruck, Anichstr. 35, Innsbruck, 6020, Austria.
Tamara KakoschkeDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital LMU Munich. Lindwurmstr. 2A, 80337, Munich, Germany.
Klaus-Dietrich WolffDepartment of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany.
Carolin GötzDepartment of Oral and Maxillofacial Surgery, Medical University of Innsbruck, Anichstr. 35, Innsbruck, 6020, Austria. carolin.goetz1@googlemail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedication-Related Osteonecrosis of the Jaw (MRONJ), an established side effect of antiresorptive and antiangiogenic medication, could sometimes require surgical intervention, such as decortication. The objectives of this retrospective patient survey study were to evaluate the effect of surgical treated MRONJ on health-related quality of life (QoL) and to assess the awareness of the risk of MRONJ.

methodsThe MRONJ-related QoL in both cancer and osteoporosis patients was determined in four different time periods after surgery applying the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30), a modified version of the Module for Head and Neck Cancer (H&N35) and MRONJ-specific questions. In addition the patients´ awareness of the risk of MRONJ when being prescribed the medication was examined. 65 patients with MRONJ (28 males and 37 females) who underwent surgery of the jaw were included in this study.

resultsIn comparison to normative data of the German population cancer and osteoporosis patients showed a reduction in their QoL in general. It was demonstrated that MRONJ causes an even further negative impact, particularly on role and social function. Amongst the MRONJ patients certain factors such as female sex, breast cancer as underlying disease, hypothyroidism, denture, nicotine abuse and multiple surgeries of the MRONJ were associated with worse QoL. The majority of patients suffered from a lack of knowledge regarding the risk of MRONJ when starting antiresorptive or antiangiogenic treatment. Unaware patients manifested worse QoL results and had to undergo more operations.

conclusionQoL of MRONJ patients is deteriorated and the number of surgeries and the patients´ awareness have a significant impact on QoL. In order to reach better awareness amongst both patients, doctors and other health care professionals and to detect MRONJ at an earlier stage, the H&N35 and MRONJ specific questions should be routinely administered to osteoporosis and cancer patients when starting antiresorptive or antiangiogenic treatment.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawQuality of LifeAdultAgedAged, 80 and overAngiogenesis InhibitorsBone Density Conservation AgentsDiphosphonatesFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedNeoplasmsOsteoporosisRetrospective StudiesAngiogenesis InhibitorsBone Density Conservation AgentsDiphosphonatesAntiangiogenic agentsAntiresorptive agentsAwarenessBisphosphonatesMRONJPostoperative outcomeQuality of life

Identifiers

PMID40544272
PMCPMC12182669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.