Evidence map›Paper›PMID 40544229›Full record

ArticleUpdates in surgery2025

Lobar versus sub-lobar resection for clinical stage IA (≤ 2 cm) lung neuroendocrine tumor with spread through air spaces: a multi-center study.

Hanbo Pan, Hang Chen, Weicheng Kong, Zhen Ge, Jiaqi Zhang, Wanyu Li, Yu Tian, Junwei Ning, Liang Fang, Zhizhuo Dai and 11 more

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hanbo Pan *Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China.
Hang Chen *Department of Cardiothoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, China.
Weicheng Kong *Department of Thoracic Surgery, Putuo District People's Hospital, Zhoushan, 316100, China.
Zhen Ge *Department of Cardiothoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315020, China.
Jiaqi Zhang *Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China.
Wanyu LiDepartment of Integrated Traditional Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
Yu TianDepartment of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China.
Junwei NingDepartment of Thoracic Surgery, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200050, China.
Liang FangDepartment of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China.
Zhizhuo DaiSchool of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China.
Guomo RuanWenzhou People's Hospital, Shanghai University, Wenzhou, 325000, China.
Zhongjie ChenDepartment of Cardiothoracic Surgery, Ningbo Beilun District People's Hospital, Ningbo, 315800, China.
Min ZhengDepartment of Thoracic Surgery, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200050, China.
Hui WangDepartment of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China.
Ming ZhangDepartment of Integrated Traditional Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
Ziming LiDepartment of Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Jia HuangDepartment of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China.
Chengwei ZhouDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315020, China.
Guodong XuDepartment of Cardiothoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, China.
Hui YinDepartment of Thoracic Surgery, The First Affiliated Hospital of Shaoyang University, 39 Tongqu Street, Shaoyang, 422001, China. dr_yinhui@126.com.
Qingquan LuoDepartment of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 241 Huaihai West Road, Shanghai, 200030, China. luoqingquan@hotmail.com.ORCID http://orcid.org/0000-0003-4098-9477

Funding

Development Center for Medical Science & Technology National Health Commission of the People's Republic of China WA2021RW27National Nature Science Foundation of China 82473210Natural Science Foundation of Shanghai 24ZR1464400Zhejiang Province Medical and Health Project 2022KY296
6 · The paper itself

Abstract

Tumor spread through air spaces (STAS) is an important prognostic factor for lung cancer, including lung neuroendocrine tumors (NETs). The comparative oncological efficacy of lobar resection (LR) and sub-lobar resection (SR) for clinical stage IA (cIA) STAS-positive NETs remains unclear. This retrospective study aimed to review outcomes in patients with consecutive peripheral cIA (tumors ≤ 2 cm) STAS-positive NET patients (excluding small cell lung cancer) who underwent surgery between 2012 and 2020 at six high-volume tertiary Chinese institutions. SR was commonly performed for patients ineligible for LR for various reasons. The primary endpoint was recurrence-free survival (RFS), while the secondary endpoint was overall survival (OS). Propensity score matching (PSM) was utilized to minimize selection bias. Among the 599 eligible patients, PSM resulted in 328 LR and 164 SR cases with well-balanced baseline characteristics. During a median follow-up of 6.8 years, LR significantly improved 5-year RFS (68.3% versus 54.3%, hazard ratio (HR) [95% confidence interval (CI)] = 0.595 [0.449-0.787], P < 0.001) and OS (79.0% versus 72.6%, HR [95%CI] = 0.650 [0.484-0.872], P = 0.025), and reduced postoperative recurrence (34.5% versus 51.2%, P < 0.001) and mortality (32.3% versus 46.3%, P = 0.002) rates compared to SR. Subgroup analysis revealed that LR improved RFS (59.2% versus 42.5%, HR [95%CI] = 0.553 [0.408-0.749], P < 0.001) and OS (74.0% versus 63.7%, HR [95%CI] = 0.710 [0.509-0.989], P = 0.043) compared to SR in patients with large cell neuroendocrine carcinoma (LCNEC), while both approaches yielded comparable prognoses in patients with carcinoid. Furthermore, segmentectomy exhibited survival outcomes comparable to those of wedge resection. Collectively, LR demonstrated better survival outcomes than SR for cIA STAS-positive NETs, with the benefit being influenced by the tumor histology. LCNEC was associated with a 3.3-fold higher risk of recurrence and a 4.0-fold higher risk of mortality than carcinoid.

Indexed as

Lung NeoplasmsNeuroendocrine TumorsPneumonectomyAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPropensity ScoreRetrospective StudiesTreatment OutcomeLobar resectionLung neuroendocrine tumorOverall survivalRecurrence-free survivalSpread through air spacesSub-lobar resection

Identifiers

PMID40544229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.