Evidence map›Paper›PMID 40544216›Full record

ArticleCommunications medicine2025

Optimal timing for atrial fibrillation patients to undergo catheter ablation.

Mingjie Lin, Huan Liang, Kai Zhang, Tongshuai Chen, Juntao Wang, Wenqiang Han, Bing Rong, Jingquan Zhong

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07512037 (Burden-Evaluated Active Therapy for AF Using Continuous Wearables BEAT-AF Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07512037 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Burden-Evaluated Active Therapy for AF Using Continuous Wearables BEAT-AF Trial

TypeinterventionalSponsorNavy General Hospital, BeijingRan2026 to 2029Enrolled3,194ConditionsAtrial Fibrillation (AF), Digital Health Intervention, Wearable MonitoringArms5D-AF Burden-Guided Active Management
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingjie Lin *State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Huan Liang *State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Kai ZhangState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Tongshuai ChenState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Juntao WangState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Wenqiang HanState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Bing RongState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. rongbinger@126.com.
Jingquan ZhongState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. 198762000778@email.sdu.edu.cn.ORCID http://orcid.org/0009-0008-7832-1425

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81970282, 82270331
6 · The paper itself

Abstract

backgroundThe optimal timing of undergoing catheter ablation for patients with atrial fibrillation (AF) remains uncertain. We aimed to investigate the impact of diagnosis-to-ablation time (DAT) on AF recurrence and major adverse cardiovascular and cerebrovascular events (MACCE) following catheter ablation.

methodsThis study analyzed prospective observational data from a single center, including 2097 participants (59.98 ± 10.57 years, 62.7% male) undergoing AF ablation between January 2016 and December 2020. Patients were stratified by DAT: ≤ 1 year, > 1 to ≤ 3 years, and > 3 years. Cox proportional hazards and logistic regression analyses were used to identify predictors of AF recurrence and MACCE.

resultsDuring the 46.89 ± 16.46 months follow-up, AF recurs in 512 patients (24.6%). A longer delay per month is significantly associated with a higher recurrence of AF based on multivariable Cox regression analysis [Hazard Ratio (HR) 1.003 (95% CI: 1.001-1.005), p = 0.015]. This association remains consistent in patients with persistent AF (HR compared to DAT ≤ 1 year: 1.548 [95% CI: 1.139-2.102], p = 0.016), but not in those with paroxysmal AF. Left atrial diameter ≥40 mm and female are identified as independent predictors of AF recurrence. The overall impact of DAT on MACCE occurrence is not significant, with age and vascular disease being independent predictors.

conclusionsEarly catheter ablation is preferable for maintaining sinus rhythm, particularly in persistent AF. However, DAT dose not influence the incidence of MACCE. These findings endorse the paradigm shift towards early ablation.

Identifiers

PMID40544216
PMCPMC12182564

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