Evidence map›Paper›PMID 40544181›Full record

ArticleNPJ vaccines2025

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate.

Rory C F de Brito, Yashar Sadigh, Joseph Bowman, Stephanie Clive, Ben Jackson, Miriam Pedrera, Fraser Crofts, Matthieu Bernard, Fabian Z X Lean, Alejandro Núñez and 3 more

Abstract read
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In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rory C F de Brito *The Pirbright Institute, Woking, UK.
Yashar Sadigh *The Pirbright Institute, Woking, UK.
Joseph Bowman *The Pirbright Institute, Woking, UK.
Stephanie CliveVirology Department, Animal and Plant Health Agency, Addlestone, UK.
Ben JacksonThe Pirbright Institute, Woking, UK.
Miriam PedreraThe Pirbright Institute, Woking, UK.
Fraser CroftsThe Pirbright Institute, Woking, UK.
Matthieu BernardPathology and Animal Sciences Department, Animal and Plant Health Agency, Addlestone, UK.
Fabian Z X LeanPathology and Animal Sciences Department, Animal and Plant Health Agency, Addlestone, UK.
Alejandro NúñezPathology and Animal Sciences Department, Animal and Plant Health Agency, Addlestone, UK.
Julian SeagoThe Pirbright Institute, Woking, UK.
Jean-Pierre FrossardVirology Department, Animal and Plant Health Agency, Addlestone, UK.
Simon P GrahamThe Pirbright Institute, Woking, UK. simon.graham@pirbright.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00007031
6 · The paper itself

Abstract

More efficacious vaccines are required to improve control of porcine reproductive and respiratory syndrome viruses (PRRSV). One strategy that has shown promise is the use of centralized antigens, generated from consensus sequence data. Here, we evaluated the consensus sequence approach to develop a PRRSV-1 modified live virus (MLV) vaccine candidate, 'EU-PRRSV-Con'. EU-PRRSV-Con strain was engineered by inserting consensus sequence open-reading frames encoding envelope proteins of 67 PRRSV-1 strains into an attenuated PRRSV-1 strain backbone. EU-PRRSV-Con was evaluated in pigs and benchmarked against a licensed MLV vaccine. Efficacy was assessed against three different PRRSV-1 isolates. Neutralizing antibodies were elicited by EU-PRRSV-Con, which were more reactive than those induced by the licensed MLV. EU-PRRSV-Con provided better levels of protection (reduced viral loads and lung pathology) than the licensed MLV, although the efficacy against a divergent PRRSV-1 subtype 3 strain was more limited. These data support the development of EU-PRRSV-Con as a vaccine that may aid control of PRRSV-1.

Identifiers

PMID40544181
PMCPMC12182563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.