Evidence map›Paper›PMID 40544133›Full record

ReviewWorld neurosurgery2025

Bioactive Therapies for Degenerative Disc Disease: Microenvironmental Foundations of Disease.

Ashley Cardenas, Alikhan B Fidai, Chibuikem A Ikwuegbuenyi, Anthony Robayo, Noah Willett, Ibrahim Hussain, Roger Härtl, Lawrence J Bonassar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ashley CardenasMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Alikhan B FidaiMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Chibuikem A IkwuegbuenyiDepartment of Neurological Surgery, Och Spine at New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.
Anthony RobayoDepartment of Neurological Surgery, Och Spine at New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.
Noah WillettDepartment of Neurological Surgery, Och Spine at New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.
Ibrahim HussainDepartment of Neurological Surgery, Och Spine at New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.
Roger HärtlDepartment of Neurological Surgery, Och Spine at New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.
Lawrence J BonassarMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, USA. Electronic address: lb244@cornell.edu.

Funding

J. NRSA Training CoreTL1TR002386 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Genevieve Giny Fouda Amou ou · 2017 to 2026
$5.8M
Combined Engineering and Orthopaedics Training ProgramT32AR078751 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A., VAN DER MEULEN, MARJOLEIN C · 2021 to 2025
$1.7M
NCATS NIH HHS TL1 TR002386NIAMS NIH HHS T32 AR078751
6 · The paper itself

Abstract

Intervertebral disc (IVD) degeneration is a common source of back pain. The IVD is a complex structure that consists of an outer annular ring, an inner nucleus pulposus, and flanking cartilaginous endplates, which together allow for daily mobility by distributing loads and acting as a flexible segment within the spine. Both age and mechanical overload can drive the development of a pathologic disc microenvironment that includes alterations in mechanics, solute transport, and inflammation. Such changes in the disc have negative consequences on resident cells that promote their senescence, apoptosis, and contribution to furthering disc degeneration through mitochondrial dysfunction and the release of reactive oxygen species, proteases, and cytokines. This crosstalk between IVD cells and their microenvironment creates a feedback loop that eventually manifests into such clinical conditions as disc height loss, herniations, and total IVD collapse. Developing a holistic understanding of how this feedback loop is initiated and may be halted will enable the development of novel therapeutics that not only provide analgesic benefit but also help rebuild the deteriorated disc.

Indexed as

Intervertebral Disc DegenerationAnimalsHumansIntervertebral DiscApoptosisInflammationMechanicsMitochondriaSenescence

Identifiers

PMID40544133
PMCPMC12366759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.