Evidence map›Paper›PMID 40543935›Full record

ArticleKidney international2025

To do or not to do-genetic testing for autosomal dominant polycystic kidney disease in children and adolescents.

Becky Mingyao Ma, Hila Milo Rasouly, Maya Sabatello

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Becky Mingyao MaDepartment of Medicine, Division of Nephrology, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong.
Hila Milo RasoulyDepartment of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, New York, USA.
Maya SabatelloDepartment of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, New York, USA; Department of Medical Humanities and Ethics, Division of Ethics, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: ms4075@cumc.columbia.edu.

Funding

Advancing equitable implementation of genomic medicine in nephrologyK01DK132495 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hila Milo Rasouly · 2022 to 2026
$722k
NIDDK NIH HHS K01 DK132495
6 · The paper itself

Abstract

Despite increasing evidence of the clinical utility of genetic testing in adults with autosomal dominant polycystic kidney disease, its benefits in asymptomatic children, including adolescents, remain controversial. Although there may be medical benefits in an early accurate molecular diagnosis for targeted disease monitoring and intervention, these benefits need to be carefully balanced against the potential legal, ethical, psychological, and socioeconomic harms for a developing child and adolescent. Comprehensive genetic counseling is essential to facilitate family-centered decision-making.

Indexed as

Genetic TestingPolycystic Kidney, Autosomal DominantAdolescentAge FactorsChildClinical Decision-MakingGenetic CounselingGenetic Predisposition to DiseaseHumans

Identifiers

PMID40543935
PMCPMC13634161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.