Evidence map›Paper›PMID 40543379›Full record

ReviewCurrent opinion in immunology2025

Beyond skin deep: total-body positron emission tomography to illuminate systemic inflammation in psoriatic arthritis.

Abhijit J Chaudhari, Yasser G Abdelhafez, Lorenzo Nardo, Siba P Raychaudhuri

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abhijit J ChaudhariDepartment of Radiology, University of California Davis, USA. Electronic address: ajchaudhari@ucdavis.edu.
Yasser G AbdelhafezDepartment of Radiology, University of California Davis, USA; Nuclear Medicine Unit, South Egypt Cancer Institute, Assiut University, Egypt.
Lorenzo NardoDepartment of Radiology, University of California Davis, USA.
Siba P RaychaudhuriDepartment of Internal Medicine - Rheumatology, University of California Davis, USA; Northern California Veterans Affairs Medical Center, Mather, CA, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PETR01CA206187 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BADAWI, RAMSEY D., CHERRY, SIMON R · 2015 to 2019
$15.5M
Total-body PET for assessing myofascial painR33AT012187 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAUDHARI, ABHIJIT J, NARDO, LORENZO · 2025 to 2025
$2.5M
Total-body PET for assessing myofascial painR61AT012187 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAUDHARI, ABHIJIT J, NARDO, LORENZO · 2022 to 2022
$2.1M
Total-Body PET/CT for assessing Rheumatoid Arthritis Disease Activity and Treatment ResponseR01AR076088 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAUDHARI, ABHIJIT J · 2019 to 2021
$617k
Characterization of Spinal Pathology in Axial Psoriatic ArthritisR01AR085314 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Abhijit J Chaudhari, SIBA P RAYCHAUDHURI · 2025 to 2026
$434k
NCCIH NIH HHS R33 AT012187NCCIH NIH HHS R61 AT012187NCI NIH HHS R01 CA206187NIAMS NIH HHS R01 AR076088NIAMS NIH HHS R01 AR085314NIH HHS P51 OD011107
6 · The paper itself

Abstract

Psoriatic arthritis (PsA) is a systemic, immune-mediated disorder characterized by inflammation across peripheral and axial joints, entheses, skin, and nails. Given this heterogeneous manifestation, PsA presents unique challenges in clinical diagnosis and management. Conventional imaging, limited to localized, anatomical assessments, often fails to capture the full spectrum of PsA's systemic inflammatory burden, particularly subclinical disease. This review explores the emerging role of total-body positron emission tomography (TB-PET), offering a comprehensive assessment of molecular and metabolic processes across all affected tissues of the body in a single, short, low-dose scan. With PET radiotracers targeting glucose metabolism, T-cell trafficking, and macrophage activation, TB-PET may serve as a gateway to assess the spectrum and degree of inflammation in all the pathologic domains underlying PsA. Ultimately, by bridging molecular imaging with immunology and observable phenotypic features, TB-PET may open new avenues for understanding the pathophysiology of PsA, impacting both research paradigms and clinical strategies.

Indexed as

Arthritis, PsoriaticInflammationPositron-Emission TomographySkinWhole Body ImagingAnimalsHumans

Identifiers

PMID40543379
PMCPMC12237434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.