Evidence map›Paper›PMID 40543363›Full record

SynthesisDrug and alcohol dependence2025

Cognitive-behavioral interventions for co-occurring substance use and mental health disorders.

Molly Magill, Emily C Helminen, Blaine Lynch-Gadaleta, Kari Allen, Brian D Kiluk, Lara A Ray

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Molly MagillBrown University, Center for Alcohol and Addiction Studies, Providence, RI, USA. Electronic address: molly_magill@brown.edu.
Emily C HelminenBrown University, Center for Alcohol and Addiction Studies, Providence, RI, USA.
Blaine Lynch-GadaletaBrown University, Center for Alcohol and Addiction Studies, Providence, RI, USA.
Kari AllenBrown University, Center for Alcohol and Addiction Studies, Providence, RI, USA.
Brian D KilukYale School of Medicine, New Haven, CT, USA.
Lara A RayUniversity of California at Los Angeles, Los Angeles, CA, USA.

Funding

Substance Abuse Intervention/Outcome Research TrainingT32DA016184 · NIDA · BROWN UNIVERSITY · PI Damaris J. Rohsenow, JENNIFER W. TIDEY · 2003 to 2026
$6.1M
Optimal Endpoints in Clinical Trials of Cognitive Behavioral Interventions for AOD: An Aggregate and Individual Patient Data Meta-AnalysisR01AA029703 · NIAAA · BROWN UNIVERSITY · PI MAGILL, MOLLY · 2022 to 2025
$2.3M
Integrating Cognitive Neuroscience Toward Understanding of Mechanisms of CBT for Alcohol Use DisordersK02AA027300 · NIAAA · YALE UNIVERSITY · PI KILUK, BRIAN D. · 2019 to 2023
$719k
NIAAA NIH HHS K02 AA027300NIAAA NIH HHS R01 AA029703NIDA NIH HHS T32 DA016184
6 · The paper itself

Abstract

The current meta-analysis provides an overview of cognitive-behaviorally-based interventions (CBI) that treat co-occurring alcohol and other drug use (AOD) and one or more mental health disorders. A literature search was conducted through October of 2024. All published outcome data were extracted and categorized into one of thirteen different outcome types (e.g., abstinence, quantity, mental health symptoms, quality of life) and two broader outcome classes (i.e., consumption; psychosocial). The study sample included 47 randomized trials (K = 101 publications; 912 effect sizes). The studies were primarily polydrug-focused and targeted samples where diagnostic criteria for a use disorder were met. CBIs targeting co-occurring disorders provided benefit over usual care and control comparators for consumption, but not psychosocial outcomes. The opposite pattern of effects was observed when CBI was added to usual care and compared to usual care alone. When a CBI treatment was compared to a CBI treatment targeting AOD or mental health only, significant effects were not observed. These results suggest modest efficacy of CBI interventions in this sample of studies targeting a range of substances and co-occurring mental health conditions.

Indexed as

Cognitive Behavioral TherapyMental DisordersSubstance-Related DisordersDiagnosis, Dual (Psychiatry)HumansRandomized Controlled Trials as TopicAlcohol treatmentCognitive-behavioralCo-occurring disordersDual diagnosisMeta-analysis

Identifiers

PMID40543363
PMCPMC13455035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.