ArticleCell reports2025
Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair.Microorganisms · 2026Review
- Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions.European journal of immunology · 2026Article
- Gut-derived, inflammatory ILC2s disseminate type 2 immunity to remote lung in food allergen-challenged mice.Journal of leukocyte biology · 2026Article
- Review
- Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell Levels in Bleomycin-Induced Pulmonary Fibrosis.The Kaohsiung journal of medical sciences · 2026Article
- Single-cell analysis of recruited ILC2 cell fate during transition from circulation to establishment of tissue residency.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- The context-dependent role of group 2 innate lymphoid cells in lung diseases.Acta biochimica et biophysica Sinica · 2026Review
- From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs.Frontiers in immunology · 2026Review
- Circadian clock-gut microbiota axis in pulmonary hypertension: linking gut-lung crosstalk, immune timing and vascular remodeling.Frontiers in physiology · 2026Review
- Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits.Immune network · 2025Review
- Levels of Exhaled Fraction of Nitric Oxide (FeNO) and Type 2 Biomarkers in Individuals Naturally Exposed to Helminth Parasites in a Tropical Region.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Circulating group 2 innate lymphoid cells (ILC2s) comprise a third of all lung ILC2s shortly after helminth infection, providing an early source of type-2 cytokines. However, the origin of circulating ILC2s and their relationship with ILC progenitors and tissue-resident ILC2s remain unresolved. Single-cell RNA-sequencing and trajectory analysis of ILC2 and ILC2 progenitors in the lung, bone marrow (BM), and intestine draining lymph nodes (LNs) revealed that circulating ILC2s in the lung mirror a population of ILC2s in the mesenteric LNs. Conversely, lung-resident ILC2s closely resembled BM ILC progenitors. These BM progenitors gave rise to lung-resident ILC2s but not circulating ILC2s after adoptive transfer. Definitive proof of an intestinal origin for circulating ILC2s in the lung was achieved through in vivo photoconversion of the intestine. These findings emphasize how rapid deployment of intestinal ILC2s to distal sites of type-2 inflammation bolsters barrier immunity to allow time for tissue-resident ILC2 expansion.
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