ArticleEpileptic disorders : international epilepsy journal with videotape2025
Modulation of neural complexity and consciousness in temporal lobe seizures: Effects of high-frequency pulvinar stimulation.
Article in Epileptic disorders : international epilepsy journal with videotape, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Thalamo-cortical synchrony shapes seizure expression in human temporal lobe epilepsy.Nature communications · 2026Article
- Semiology in spontaneous versus cortical stimulation-induced seizures during SEEG: A within-patient comparison study.Epilepsia open · 2026Article
- Medial pulvinar stereoelectroencephalographic biomarkers associated with deep brain stimulation response in focal drug-resistant epilepsy.Epilepsia · 2026Article
- Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective.Frontiers in neuroanatomy · 2026Review
- Modulation of neural complexity and consciousness in temporal lobe seizures: Effects of high-frequency pulvinar stimulation.Epileptic disorders : international epilepsy journal with videotape · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundLoss of consciousness/awareness during temporal lobe seizures significantly affects quality of life and is closely linked to pathological thalamocortical synchronization and loss of cortical signal complexity. The medial pulvinar nucleus (PUM) contributes to seizure propagation and awareness impairment, making it a potential target for neuromodulation. Acute high-frequency PUM stimulation has previously been shown to reduce seizure severity and improve awareness, potentially by disrupting excessive synchrony.
aimsIn this study, we investigated the effects of PUM stimulation on signal complexity and its relationship to ictal awareness using permutation entropy (PE) in SEEG recordings. MATERIALS AND
methodsEight patients with focal drug-resistant temporal epilepsy underwent hippocampus-induced seizures with and without additional high-frequency PUM stimulation. SEEG complexity changes were quantified using PE and ictal awareness was assessed using the Consciousness Seizure Scale (CSS).
resultsOur results showed that PUM stimulation attenuated entropy reductions during seizures, suggesting a preservation of neural complexity. Moreover, reduced entropy alterations correlated with improved CSS scores. DISCUSSION: These findings support the role of PUM stimulation in mitigating pathological neural complexity alterations, with potential implications for preserving both consciousness and cognitive function in epilepsy.
conclusionFurther studies are needed to confirm these findings in larger cohorts and to explore the long-term effects of thalamic deep brain stimualtion in drug-resistant epilepsy as well as the interaction between neural complexity, awareness, and cognition in this context.
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