Evidence map›Paper›PMID 40543008›Full record

Trial reportUpdates in surgery2026

Air leaks management using polymeric hydrogel matrix after thoracoscopic lung segmentectomy: a single-center prospective randomized trial with a cost-effective analysis.

Samuele Nicotra, Giovanni M Comacchio, Marco Mammana, Viola Sambataro, Giulia Pagliarini, Alessandro Bonis, Deris Boemo, Pietro Bovo, Alessandro Rebusso, Marco Schiavon and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06544200 (Intra-operative Air Leak Management After Minimally Invasive Lung Segmental Resection), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06544200 nacompletednot on this map

Intra-operative Air Leak Management After Minimally Invasive Lung Segmental Resection: Randomized Comparison Between Polymeric Hydrogel Matrix and Standard of Care

TypeinterventionalSponsorUniversity Hospital PadovaRan2023 to 2024Enrolled104ConditionsLung Cancer Stage I, Lung, Node, Air Leak From LungArmsPolymeric Hydrogel Matrix
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Samuele NicotraDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy. samuele.nicotra@aopd.veneto.it.
Giovanni M ComacchioDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Marco MammanaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Viola SambataroDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Giulia PagliariniDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Alessandro BonisDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Deris BoemoDepartment of Directional Hospital Management, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Pietro BovoManagement Control Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Alessandro RebussoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Marco SchiavonDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Giorgio CannoneDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Eleonora FaccioliDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Andrea Dell'AmoreDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Federico ReaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, Thoracic Surgery Unit, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlveolar air leaks are common complications after thoracoscopic lung resections, increasing morbidity, hospital stay, and costs. Polymeric hydrogel matrix (PHM) has shown effectiveness in reducing air leaks and chest tube duration after lobectomy. This study aims to assess PHM's impact on air leaks, chest drain duration, hospital stay, and its cost-effectiveness following thoracoscopic segmentectomies. MATERIALS AND

methodsPatients with moderate intraoperative alveolar air leaks during thoracoscopic lung segmentectomy were randomized to receive either PHM (PHM Group) or standard care (SC Group). A cost-effectiveness analysis compared surgical materials between PHM and SC procedures.

resultsOut of 109 screened patients, 60 were randomized into the two groups. No differences were found in baseline characteristics, surgical procedures, or complications. However, the PHM group had significantly shorter durations for air leaks (p = 0.01), chest drain stay (p = 0.01), and hospital stay (p = 0.01). The PHM group had higher procedure expenses (p = 0.02), but a single day of early discharge offset this cost.

conclusionThis prospective trial shows that PHM application in thoracoscopic lung segmentectomies with moderate intraoperative air leaks significantly reduces postoperative air leaks, chest tube duration, and hospital stay. Additionally, the cost-effectiveness analysis supports PHM's potential to expand surgical capacity.

trial registrationClinical Trials, www. CLINICALTRIALS: gov , NCT06544200.

Indexed as

Cost-Effectiveness AnalysisHydrogelsPneumonectomyPneumothoraxPolymersPostoperative ComplicationsThoracic Surgery, Video-AssistedAgedChest TubesFemaleHumansLength of StayMaleMiddle AgedProspective StudiesThoracoscopyHydrogelsPolymersAir leaksPolymeric hydrogel matrixSegmentectomyVATS

Identifiers

PMID40543008

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.