ArticleVeterinary research communications2025
Effects of central injection of liver-expressed antimicrobial peptide-2 (LEAP2) on feed intake in broiler chickens: interactions with opioidergic and serotonergic systems.
Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Investigation of cholecystokinin-8s-induced hypophagia in neonatal broiler chicks: Roles of central adrenergic and serotonergic systems.IBRO neuroscience reports · 2026Article
- Central βVeterinary research communications · 2026Article
- Article
- Central administration of C-type natriuretic peptide (CNP) modulates food consumption in broilers: involvement of dopaminergic, melanocortinergic, and neuropeptide Y receptors.Veterinary research communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver-expressed antimicrobial peptide-2 (LEAP2) is recognized for its role in regulating meal consumption in mammals, but its function in avian species, especially broiler chickens, is not well understood. This study investigates the impact of central LEAP2 injection on food intake in broiler chickens, and explores its interactions with the opioidergic and serotonergic systems. Across eight trials, we examined the relationships between these systems and LEAP2 concerning meal intake in meat-type chickens. In Experiment 1, broilers received an intracerebroventricular (ICV) infusion of LEAP2 (0.75, 1.5, and 3 nmol) alongside a control solution. Subsequent experiments involved injecting birds with β-FNA (mu opioid receptor antagonist), LEAP2 (3 nmol), and β-FNA + LEAP2 (Experiment 2), with Experiments 3-8 following a similar design, substituting β-FNA with nor-BNI (kappa opioid receptor antagonist), NTI (delta opioid receptor antagonist), PCPA (serotonin synthesis inhibitor), fluoxetine (serotonin reuptake inhibitor), 8-OH-DPAT (5-HT1A receptor agonist), and SB242084 (5-HT2C receptor antagonist). Cumulative meal consumption was measured for 120 min post-infusion. Results indicated that LEAP2 injection (1.5 and 3 nmol) significantly reduced feed intake in broilers compared to the control treatment (P < 0.05). Co-infusion of β-FNA, PCPA, and SB242084 + LEAP2 attenuated LEAP2-induced hypophagia (P < 0.05), while co-infusion of fluoxetine + LEAP2 amplified LEAP2-induced hypophagia compared to the control treatment (P < 0.05). These findings suggest that LEAP2 induces hypophagic effects in broiler chickens, potentially mediated through the mu opioid and 5-HT2C receptors.
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Registered trials
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