Evidence map›Paper›PMID 40542980›Full record

ArticleJapanese journal of ophthalmology2025

Reconsideration of conversion to multiple sclerosis: one-year cerebral lesion appearance rate of Japanese aquaporin-4 antibody-negative optic neuritis patients.

Satoshi Ueki, Yukari Hasegawa, Tetsuhisa Hatase, Izumi Kawachi, Takeo Fukuchi

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Article in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Satoshi UekiDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi-dori 1-757, Chuo-ku, Niigata, 951-8510, Japan. sueki@med.niigata-u.ac.jp.ORCID http://orcid.org/0000-0002-7199-6111
Yukari HasegawaDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi-dori 1-757, Chuo-ku, Niigata, 951-8510, Japan.
Tetsuhisa HataseDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi-dori 1-757, Chuo-ku, Niigata, 951-8510, Japan.
Izumi KawachiDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Takeo FukuchiDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi-dori 1-757, Chuo-ku, Niigata, 951-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the rate of new cerebral lesions' appearance within 6-12 months in Japanese optic neuritis patients who at onset had no cerebral lesions suggestive of multiple sclerosis (MS) and were negative for aquaporin-4 (AQP4) antibodies. STUDY

designRetrospective study.

methodsMedical records of 66 adult patients with optic neuritis were reviewed. Patients positive for AQP4, myelin oligodendrocyte glycoprotein, or antinuclear antibodies were excluded. Those without cerebral lesions on initial magnetic resonance imaging (MRI) underwent follow-up MRI within 6-12 months. Clinical characteristics and subsequent neurological diagnoses were analyzed.

resultsForty-seven patients met the inclusion criteria (mean age, 41.9±16.7 years; 13 men, 34 women). Forty-two cases were unilateral, five bilateral; 19 had disc swelling, and 28 did not. The mean worst logMAR was 1.13±0.96. Two patients experienced recurrence within 1 year. Of the 27 patients without initial cerebral lesions, 20 underwent follow-up MRI; 3 (15%) developed new lesions. These three were later diagnosed as two MS and one suspected MS cases.

conclusionFollow-up MRI within 6-12 months revealed new cerebral lesions in 15% of patients, with 10% diagnosed with MS. This highlights the importance of follow-up imaging even in AQP4 antibody-negative optic neuritis patients without initial cerebral lesions, especially in the absence of other diseases like neuromyelitis optica spectrum disorders.

Indexed as

Aquaporin 4AutoantibodiesMultiple SclerosisOptic NeuritisAdultDisease ProgressionFemaleFollow-Up StudiesHumansJapanMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTime FactorsVisual AcuityAQP4 protein, humanAquaporin 4AutoantibodiesAquaporin-4 antibodiesCerebral lesionsFollow-up magnetic resonance imagingMultiple sclerosisOptic neuritis

Identifiers

PMID40542980

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