ReviewCurrent urology reports2025
Packing the Punch: Current and Emerging Treatment Strategies in Metastatic Castration-Sensitive Prostate Cancer.
Review in Current urology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Real-World PSA Response and Overall Survival Among Men with mCSPC Receiving Apalutamide Versus Darolutamide (Both Without Docetaxel) in the US.Advances in therapy · 2026Article
- Real-world comparative effectiveness of apalutamide versus enzalutamide for prostate-specific antigen response in metastatic castration-sensitive prostate cancer.Therapeutic advances in medical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewProstate cancer remains a significant source of morbidity and mortality worldwide, with metastatic castration-sensitive disease (mCSPC) representing a complex therapeutic challenge. This review explores how a deeper understanding of the androgen receptor axis has shifted mCSPC management from monotherapy to more intense treatment. We discuss emerging data on triplet regimens, targeted therapies, and the role of local treatment. RECENT
findingsRandomized trials have shown that adding docetaxel or androgen receptor signaling inhibitors (ARSIs) to androgen deprivation therapy (ADT) improves survival. Triplet therapy (ADT, docetaxel, and an ARSI) improves outcomes in patients with high-volume disease compared to ADT and docetaxel alone, although comparisons to ADT plus ARSI doublet therapy are ongoing. The early use of targeted radionuclides, biomarker-driven therapies, and metastasis-directed radiotherapy has also emerged, potentially refining treatment personalization in clinical practice. Current guidelines recommend ADT combined with an ARSI, with the addition of docetaxel reserved for high-volume disease. Future research aims to optimize intensity, inform biomarker-driven strategies, and reduce toxicity. Advancements in management of mCSPC underscore the importance of a multimodal, personalized approach to improve outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.