Evidence map›Paper›PMID 40542865›Full record

Trial reportEuropean journal of applied physiology2025

Acute sodium bicarbonate supplementation reduces the increase in markers of acute kidney injury during physical work in the heat.

Abdulaziz A Masoud, Zidong Li, Michael R Deyhle, Jason Siegler, Jonathan Specht, Zachary J McKenna, Christine Mermier, Fabiano Amorim

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdulaziz A MasoudDepartment of Educational Sciences, Jazan University, 45142, Jazan, Saudi Arabia. amasoud@jazanu.edu.sa.ORCID http://orcid.org/0009-0009-8730-9986
Zidong LiDepartment of Molecular Biology & Chemistry, Christopher Newport University, Newport News, VA, 23606, USA.
Michael R DeyhleDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM, 87131, USA.
Jason SieglerHuman Performance Laboratory, Arizona State University, Phoenix, AZ, 85054, USA.
Jonathan SpechtDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM, 87131, USA.
Zachary J McKennaInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, TX, USA.
Christine MermierDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM, 87131, USA.
Fabiano AmorimDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM, 87131, USA.

Funding

Jazan University GSSRD-25
6 · The paper itself

Abstract

introductionIn response to metabolic acidosis, compensatory mechanisms are deployed by the kidney to maintain acid-base homeostasis. During physical work in the heat, kidney perfusion is reduced, and the metabolic cost of acid-base balance can make the kidneys more prone to acute kidney injury (AKI). Sodium bicarbonate ingestion (NaHCO PURPOSE: We tested the hypothesis that acute NaHCO

methodsIn a randomized double-blinded placebo-controlled crossover design 8 participants (3 females) completed 2 h of walking at 65% of maximal heart rate in 40 °C and ~ 20% relative humidity (RH) with NaHCO

resultsThe increase in IGFBP7 × TIMP-2 was lower with NaHCO

conclusionThese findings suggest that acute NaHCO

Indexed as

Acute Kidney InjuryHot TemperatureSodium BicarbonateAdultBiomarkersCross-Over StudiesDietary SupplementsDouble-Blind MethodFemaleHumansInsulin-Like Growth Factor Binding ProteinsLipocalin-2MaleTissue Inhibitor of Metalloproteinase-2BiomarkersInsulin-Like Growth Factor Binding ProteinsLCN2 protein, humanLipocalin-2Sodium BicarbonateTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2Kidney functionOccupational workerPhysical work

Identifiers

PMID40542865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.