ArticleArchives of gynecology and obstetrics2025
Expression of growth factors in buffalo ovarian tissue across different follicular developmental stages.
Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Antioxidant and anti-apoptotic effects of curcumin-loaded nanoliposomes against di-n-butyl phthalate-induced hepatorenal damage in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The Impact of Oxidative Stress Imbalance on Ovarian Function and Its Mechanisms.International journal of general medicine · 2026Review
- Astragalus polysaccharides protect against Di-n-butyl phthalate-induced testicular damage by modulating oxidative stress, apoptosis, and the PI3K/Akt/mTOR pathway in rats.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn assisted reproduction, poor ovarian response to stimulation negatively affects oocyte yield and is influenced by genetic factors.
objectiveThis study aimed to quantify the mRNA expression of key growth markers (BMP15, GDF9, OCT4, and FGFR2) in ovarian tissue according to the developmental stages of the follicle.
methodsSamples were collected from ovarian tissue. Gene expression levels were analyzed using RT-qPCR. In addition, ELISA was used to measure the concentrations of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), along with reactive oxygen species (ROS) and malondialdehyde (MDA) as oxidative stress markers.
resultsOCT4 expression was similar in preantral and small follicles but significantly upregulated in medium and large follicles. GDF9 expression and SOD activity were highest in small follicles (P < 0.05). BMP15 levels were significantly elevated in small and medium follicles compared to preantral follicles but remained unchanged in large follicles (P < 0.05). FGFR2 expression increased progressively with follicle size (P < 0.05). GPx activity was directly proportional to follicle size, with the lowest levels in preantral follicles. Conversely, ROS, MDA, and CAT concentrations decreased as follicle size increased.
conclusionThese findings provide insights into the molecular regulation of follicular development in buffalo, which could aid in improving reproductive efficiency in assisted reproduction programs.
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