ReviewArchives of microbiology2025
Prospective on Alkaloids-based sustainable methods to treat fungal pathogens: a comprehensive review.
Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Berberine as a Promising Antifungal Agent: Insights into Molecular Mechanisms and Therapeutic Potential.ACS omega · 2026Review
- Integrated in Vitro and in Silico Investigation of Antimicrobial, Anti-biofilm, and Quorum-Sensing Inhibitory Activities of Allium atroviolaceum Bulb Extract.Applied biochemistry and biotechnology · 2026Article
- A multi-barrier defence strategy using plant-derived antifungals against mycotoxigenic fungi in livestock feed.Archives of microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of antimicrobial drugs has become essential due to the increasing resistance among microorganisms, largely driven by the indiscriminate use of antibiotics. Similarly, the misuse of antifungal agents over recent decades has contributed to the emergence of numerous drug-resistant fungal strains. The World Health Organization (WHO) recognizes antibiotic resistance as one of the top ten global public health threats. Infections caused by multidrug-resistant microorganisms are steadily rising, presenting a major challenge in modern medicine. Alkaloids represent one of the largest classes of natural compounds. These plant-derived chemicals play a defensive role, protecting plants against microorganisms, herbivores, and pests. Many alkaloids exhibit diverse biological activities, and some have been successfully developed into therapeutic agents with various pharmacological properties. This review explores a wide spectrum of plant-derived alkaloids with potential antifungal activity. Notable alkaloid classes include pyridines, quinolizidines, indoles, tropanes, piperidines, purines, imidazoles, and isoquinolines. These compounds can inhibit the growth and activity of various fungal species. While previous reviews have mentioned the general biological activity of natural and synthetic alkaloids, few have provided an in-depth analysis of their antifungal mechanisms. In this review, we discuss several primary antifungal mechanisms, including inhibition of fungal cell wall synthesis, disruption of cell membrane permeability, interference with fungal metabolism, and suppression of nucleic acid and protein synthesis. Our findings highlight that plant-derived alkaloids play a significant role in combating fungal pathogens, including drug-resistant strains. Therefore, alkaloids hold promising potential as effective agents against multidrug-resistant fungi. This review aims to address the urgent issue of antifungal resistance and offer a scientific foundation for the development of novel antifungal therapies.
Indexed as
Identifiers
40542845What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.