ArticleArchives of microbiology2025
Efficient mining of natural products from Mangrove streptomyces using NP-PRESS.
Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Streptomyces-derived natural products are an important source of lead compounds for drug discovery. Traditional methods for mining these compounds are costly, time-consuming, and labor-intensive. To address these challenges, we applied NP-PRESS, a two-stage metabolome refining pipeline, to Streptomyces speibonae W307, isolated from a mangrove environment. We conducted a thorough analysis of molecular features using NP-PRESS, leading to the identification of three natural products named strepyrazinones A, B, and C, two of which possess new structures. These compounds were characterized using high-resolution MS and NMR, with their configurations determined through ECD calculations. Additionally, we proposed their corresponding biosynthetic gene cluster and putative biosynthetic pathways.
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