ArticleAsian Pacific journal of cancer prevention : APJCP2025
Antioxidant property of Silver Nanoparticles Loaded with Alcoholic Extraction of Lycium Shawii.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAntioxidants play a crucial role in mitigating oxidative stress associated with cancer progression. Lycium shawii is noted for its high content of antioxidants and anti-inflammatory compounds. Silver nanoparticles (AgNPs) stand out as the best among the numerous synthesized and characterized nanoparticles that have been made thus far just to give an example.
objectiveThis study is carried out to synthesize, characterize and later investigate the in vivo antioxidant activity of AgNPs loaded with the alcoholic extract of Lycium shawii.
methodsThirty rats were randomly distributed among five groups. Each group contained six rats. Group 1 (Control) was given 1 mL of normal saline orally daily through a stomach tube. Group 2 was injected with 1 mL of AgNPs at a dose of 100 mg/kg for one day only. Group 3 was treated with 1 mL/day of Acetamiprid at a dose of 25 mg/kg. Group 4 was given AgNPs (100 mg/kg) for three weeks and then treated with Acetamiprid (25 mg/kg) for an additional three weeks. Group 5 was treated with Acetamiprid (25 mg/kg) for three weeks and then AgNPs (100 mg/kg). All treatments were done daily. Serum levels of T-AOC and TOS as well as AST, ALT, urea, and creatinine were measured in all groups.
resultsA statistically significant rise in TOS, ALT, AST, urea, and creatinine, along with a statistically significant reduction in T-AOC were observed (p ≤ 0.05) in Group 3 as compared to Groups 1, 2, 4, and 5.
conclusionIn vivo results showed that AgNPs, especially in combination with Lycium shawii extracts, seemed to exhibit high antioxidant activity, and was able to provide protection against oxidative stress. Retrieval of these results could contribute to a good indication about the potential use of AgNPs in cancer treatment, and as a drug in pandemic of oxidative stress-mediated disease. The molecular basis of its antioxidant effects and the long-term safety and efficacy of the use of AgNPs in clinical practice are yet to be determined.
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